David

Investigative reporter Andrew Worth turns down a documentary on a mysterious new mental illness - "Distress," or acute clinical anxiety syndrome, for another assignment. He's on his way to the artificial island of Stateless, where the world's top physicists are gathering to decide on a new TOE, or Theory of Everything, to replace Einstein's outmoded legacy.

One hundred and thirty years ago Eadweard Muybridge invented stop-motion photography, anticipating and making possible motion pictures. He was the first to capture time and play it back for an audience, giving birth to visual media and screen entertainments of all kinds. Yet the artist and inventor Muybridge was also a murderer who killed coolly and meticulously, and his trial is one of the early instances of a media sensation.

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.

From Ancient Rome to the British Empire, Phillips demonstrates that every world-dominating power has been brought down by a related set of causes: a lethal combination of global over-reach, militant religion, resource problems, and ballooning debt. It is this same axis of ills that has come to define America's political and economic identity in the past decade.

The epic, never-before-told story of Columbus's final, and perhaps greatest, journey to the New World. The final voyage of Christopher Columbus was by far his most dangerous, unexpected, exhilarating, and consequential. It was, as Pulitzer Prize-winner Samuel Eliot Morison put it, "a story of adventure which imagination could hardly invent; a struggle between man and the elements, in which the most splendid manifestations of devotion, loyalty and courage are mingled with the vilest human passions."