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Sisters. Strangers. Survivors. More than 20 years ago, Claire and Lydia's teenaged sister Julia vanished without a trace. The two women have not spoken since, and now their lives could not be more different. Claire is the glamorous trophy wife of an Atlanta millionaire. Lydia, a single mother, dates an ex-con and struggles to make ends meet. But neither has recovered from the horror and heartbreak of their shared loss—a devastating wound that's cruelly ripped open when Claire's husband is killed.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....

John Puller's older brother, Robert, was convicted of treason and national security crimes. His inexplicable escape from prison makes him the most wanted criminal in the country. Some in the government believe that John Puller represents their best chance at capturing Robert alive, and so Puller takes on the burden of bringing his brother in to face justice.