Episode 7: Why You Should Be Taking Vitamin K2 Podcast Por arte de portada

Episode 7: Why You Should Be Taking Vitamin K2

Episode 7: Why You Should Be Taking Vitamin K2

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 Episode 7: Why You Should Be Taking Vitamin K2 Host: Dr. Ravi Kumar MDTopic: A comprehensive look at vitamin K2’s discovery, mechanisms, clinical evidence, and why it’s essential for calcium homeostasis, bone strength, and vascular health. 📖 Episode Overview Historical journey from Weston A. Price’s “Activator X” to the Nobel‐winning discovery of vitamin KBiochemical roles of K1 vs. K2: activating clotting factors vs. directing calcium into bones and out of arteriesAncestral dietary patterns that once guaranteed year-round vitamin K2 intakeKey clinical findings on bone mineral density, fracture risk, arterial calcification, and beyondDrug interactions: how warfarin and statins inadvertently disrupt K2 pathwaysSupplementation strategy: MK-7 vs. MK-4, practical dosing, and Dr. Kumar’s personal protocolNext episode teaser on omega-3 fatty acids✨ Key TakeawaysVitamin K2 (menaquinones) is indispensable for proper calcium placement—bones vs. arteries.Traditional diets provided K2 via seasonal greens and fermented foods; modern diets are often deficient.Meta-analyses and RCTs demonstrate up to 57% fewer fractures and slower arterial calcification with K2.MK-7 (180–375 µg/day) offers superior bioavailability and tissue delivery compared to MK-4.Pair K2 with vitamin D and dietary fat for optimal absorption.📚 References & Study SummariesDietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease in Older Men and WomenProspective cohort of older adults showing that higher dietary menaquinone (vitamin K2) intake was linked to a significant reduction in coronary heart disease incidence.ScienceDirectVitamin K2 Ameliorates Osteoarthritis by Suppressing Ferroptosis and Extracellular Matrix Degradation Through Activation of GPX4Preclinical rodent study demonstrating that MK-7 improves cartilage integrity, reduces pain scores, and lowers osteoarthritis severity by inhibiting ferroptosis and activating the antioxidant enzyme GPX4.ScienceDirectMultiple Dietary Vitamin K Forms Are Converted to Tissue MK-4 in MiceAnimal feeding trial revealing that dietary phylloquinone (K1) and various menaquinones (MK-4, MK-7, MK-9) all serve as precursors for tissue MK-4, highlighting a common conversion pathway across tissues.ScienceDirectRole of Menaquinone-7 in Bone Health: A Comprehensive ReviewSystematic review in Frontiers in Nutrition summarizing mechanistic and clinical evidence for MK-7’s effectiveness in enhancing bone mineral density, reducing fracture risk, and exhibiting an excellent safety profile.Frontiers in NutritionEffect of Vitamin K2 on Bone Mineral Density and Fracture Risk in Postmenopausal WomenMeta-analysis of RCTs involving over 6,400 participants, showing that VK2 supplementation (primarily MK-4 and MK-7) significantly improved lumbar spine BMD and lowered overall fracture risk by approximately 57%.PubMedVitamin K Status in Chronic Kidney Disease and Hemodialysis PatientsObservational study reporting elevated levels of undercarboxylated vitamin K-dependent proteins (dp-ucMGP, ucOC) in CKD and dialysis cohorts, indicating widespread subclinical K deficiency in these populations.PMCDietary Vitamin K Intake and Bone Health in Public-Health PopulationsPopulation-level analysis linking higher dietary vitamin K intake to reduced osteoporosis prevalence and fewer fractures among older adults, reinforcing the public-health importance of K.Frontiers in Public HealthHigh-Dose MK-7 Supplementation and Vascular Calcification MarkersDouble-blind RCT (360 µg MK-7/day for 3 months) demonstrating marked reductions in dp-ucMGP—a biomarker of vascular calcification risk—in healthy volunteers.PubMedLong-Term MK-4 Therapy Prevents Vertebral Fractures in Osteoporotic WomenClinical trial showing that 45 mg/day MK-4 over 3 years significantly lowered the incidence of new vertebral fractures compared to control, despite pharmacologic dosing far above dietary levels.PubMedComparative Pharmacokinetics of MK-7 vs. MK-4 in HumansPharmacokinetic study revealing that MK-7 has a substantially longer half-life and higher steady-state blood levels than MK-4 when administered orally, supporting MK-7’s use in supplementation.PubMedEffect of Low-Dose MK-7 on Osteocalcin CarboxylationControlled trial finding that 180 µg/day of MK-7 for 12 weeks significantly increased the ratio of carboxylated to undercarboxylated osteocalcin, indicating enhanced bone-matrix protein activation.PubMedRegional Differences in Vitamin K2 Biomarkers and Bone HealthCross-sectional study of Japanese adults correlating serum K2 levels (MK-7) with superior bone density measures and lower fracture prevalence across regions with habitual natto consumption.SpringerLinkTraditional Dietary Sources of Vitamin K2 in Japanese CommunitiesEthnographic dietary survey documenting seasonal consumption of natto, fermented vegetables, and dairy in rural Japanese villages, with measured K2 intakes averaging >300 ...
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