We are 40 years into the future, and London is a city in decay. John Watson has returned from medical service in the war in Afghanistan and lives by himself in a run-down part of ​town. On his way home from work, he stumbles upon a beaten man in the street – unconscious and completely naked. His chances of survival are minimal. The same evening, a passenger plane crashes in Richmond Park. There are several hundred victims, and Watson and the mysterious man are left to their own devices.

"There is a spirit that moves amongst us. They call him the Messenger of Death. And tonight... tonight... he called my name." The Loxworths are a family of clairvoyant mediums. Sitters at their seances are dying. Their deaths predicted by a mysterious entity known as The Messenger of Death. Holmes, Watson, and Lestrade must stop the deaths, before someone close to them becomes the next victim.

From the Supernatural Case Files of Sherlock Holmes London's most beloved detective encounters his most deadly foe, and the results will be unlike any Sherlock Holmes adventure before it!

Fourteen stories, all in classic style, introduce Holmes to new clients with strange and quirky problems. Clues to a fortune are hidden in a ludicrous painting, a modern mummy walks, and a novel tourist attraction holds the key to why an unattractive lady is suddenly pursued by an amorous admirer.

What's behind a series of mysterious deaths among the favourite concubines of Sultan of Turkey, Abdul Hamid II? Suspecting a plot against himself, the Sultan has called on Sherlock Holmes to investigate. However, as a man, the detective is clearly unable to penetrate the exotic enclosed world of the harem, so he reluctantly enlists the help of his landlady, Mrs Hudson. Together with Dr Watson, they travel across Europe by Orient Express to Constantinople, on the way encountering Holmes's old enemy, Baron Mauterpuis.