In this "celebration of midlife and all its marvelous messiness,” Lisa Darling, a high-flying TV executive and twice-divorced mother of two, is navigating life with an opinionated teenager and a pet-obsessed grade-schooler, organizing PTA events, and supporting her best friend through breast cancer treatment, all while in the throes of perimenopause. It’s no wonder her to-do list is on overdrive and she never has time for Pilates or that DIY interior design project she keeps setting aside.

In the summer of 1996, teenage Tess Murphy’s mom gave her two rules to abide by: keep quiet and stay out of trouble. Her mother landed a new job as a cook at an affluent Virginia estate and didn’t want anything to risk the opportunity, least of all her outspoken daughter. What no one saw coming was Tess falling deeply in love with the boy next door, high-society Grant Alexander.

Adela Woods is sixteen years old and pregnant. Her parents banish her from her comfortable upbringing in Indiana to her grandmother’s home in the small town of Padua Beach, Florida. When she arrives, Adela meets Emory, who brings her newborn to high school, determined to graduate despite the odds; Simone, mother of four-year-old twins, who weighs her options when she finds herself pregnant again; and the rest of the Girls, a group of outcast young moms who raise their growing brood in the back of Simone’s red truck.

Jia Song has always been destined for greatness. As the daughter of Korean bodega owners, she promised herself that she would have every Fifth Avenue luxury when she grew up, and it is all finally within reach. She has just made junior partner at her prestigious Manhattan law firm, she can count on her two best friends to have her back, and she is about to score the ultraluxe gold-on-gold Birkin bag of her dreams. So when her boss asks her to sit in on the hush-hush family implosion of a high-level client, she accepts without hesitation.

Amy Lin never expected to find a love like the one she shares with her husband, Kurtis, a gifted young architect who pulls her toward joy, adventure, and greater self-acceptance. On a sweltering August morning, only a few months shy of the newlyweds’ move to Vancouver, thirty-two-year-old Kurtis heads out to run a half-marathon with Amy’s family. It’s the last time she sees her husband alive.

What is the difference between men and women? Jennifer Finney Boylan, bestselling author of She’s Not There and co-author of Mad Honey with Jodi Picoult, examines the divisions—as well as the common ground—between the genders, and reflects on her own experiences, both difficult and joyful, as a transgender American.

Ever since her dad left them twenty years ago, it’s just been Madeline Hill and her mom on their farm in Coalfield, Tennessee. While she sometimes admits it’s a bit lonely and a less exciting life than she imagined for herself, it’s mostly OK. Mostly. Then one day Reuben Hill pulls up in a PT Cruiser and informs Madeline that he believes she’s his half sister.

Joni Lark has a secret. She’s one of the most coveted songwriters in LA, and yet she can’t write. There’s an emptiness inside her, and nothing seems to fill it. When she returns to her hometown of Vienna Shores, North Carolina, she hopes that the sand, the surf, and the concerts at The Revelry, her family’s music venue, will spark inspiration. But when Joni gets there, nothing is how she left it. Her best friend is hiding something, her mother’s memories are fading fast, and The Revelry is closing.

Florence Grimes is a thirty-one-year-old party girl who always takes the easy way out. Single, broke and unfulfilled after the humiliating end to her girl band career, she has only one reason to get out of bed each day: her ten-year-old son Dylan. But then Alfie Risby, her son’s bully and the heir to a vast frozen food empire, mysteriously vanishes during a class trip, and Dylan becomes the prime suspect. Florence, for once, is faced with a task she can’t quit: She’s got to find Alfie and clear her son’s name, or risk losing Dylan forever.

When a state trooper appeared at Rachel Zimmerman’s door to report that her husband had jumped to his death off a nearby bridge, she fell to her knees, unable to fully absorb the news. How could the man she’d married, a devoted father and robotics professor at MIT, have committed such a violent act? How would she explain this to her young daughters? And could she have stopped him? A longtime journalist, she probed obsessively, believing answers would help her survive. She interviewed doctors, suicide researchers, and a man who jumped off the same bridge and lived.

At sixty-three years old, million-dollar lottery winner PJ Halliday would be the luckiest man in Pondville, Massachusetts, if it weren’t for the tragedies of his life: the sudden death of his eldest daughter and the way his marriage fell apart after that. Since then, PJ spends both his money and his time at the bar, and he probably doesn’t have much time left—he’s had three heart attacks already. But when PJ reads the obituary of his old romantic rival, he realizes his high school sweetheart, Michelle Cobb, is finally single again.

In the wake of a catastrophic storm, Cora sets off with her nine-year-old daughter, Maia, to register her son's birth. Her husband, Gordon, a local doctor, respected in the community but a terrifying and controlling presence at home, intends for her to name the infant after him. But when the registrar asks what she'd like to call the child, Cora hesitates...

Despite managing bookstores on the same Boston street, Josie Klein and Ryan Lawson have never interacted much—Josie’s store focuses on serious literature, and Ryan’s sells romance only. But when the new owner of both stores decides to combine them, the two are thrust into direct competition. Only one manager will be left standing, decided by who turns the most profit over the summer.

2016: Thirty-four-year-old Mari Starwood is still grieving after her mother’s death as she travels to the storied island of Martha’s Vineyard, off the coast of Massachusetts. She’s come all the way from California with nothing but a name on a piece of paper: Elizabeth Devereaux, the famous but reclusive Vineyard painter. When Mari makes it to Mrs. Devereaux’s stunning waterfront farm under the guise of taking a painting class with her, Mrs. Devereaux begins to tell her the story of the Smith sisters, who once lived there.

If your twenties are supposed to be the best years of your life, Bennet Taylor is failing miserably . . . with a big emphasis on the miserable. Where’s that zest she keeps hearing about? She’s a temp worker in New York City with no direction, no future, and no social life. And at the painful center of this listlessness is grief over the death of her first love.