After being educated in the east, Deborah Vandermark returns to Perkinsville, Texas, where her family is part of the thriving logging industry. She brings along an unexpected companion—her best friend, who is fleeing a wedding and groom she has no interest in. A determined matchmaker, Deborah sets her sights on uniting her brother and friend in what she hopes will be a true love match.

Recently widowed Susanna Jenkins has decided to follow her family to the booming town of San Marcial, New Mexico, for a fresh start and to aid in her family's sudden change in fortune. They are tasked with managing her uncle's new Grand Hotel, and it takes all her patience to try to help her parents see the good of their circumstances and relinquish their sense of entitlement.

In 1869, Gloriana Womack's family is much smaller since smallpox killed her mother and two of her siblings. She lives in a modest cottage in Duluth, Minnesota, with her father and young brother, and she has dedicated her life to holding her tiny, fractured family together - especially as her father is frequently gone on long fishing trips. Their livelihood may come from the waters of Lake Superior, but storms on the lake can be dangerous, even to those who know it well. Luke Carson has come to Duluth to help shepherd the arrival of the railroad to the city's port.

Addie Bryant is haunted by her past of heartbreak and betrayal. After her beau, Isaac Hanson, left the Yukon, she made a vow to wait for him. When she's sold to a brothel owner after the death of her father, Addie manages to escape with the hope that she can forever hide her past and the belief that she will never have the future she's always dreamed of. Years later, Addie has found peace in her new life as a photographer, training Camera Girls to operate and sell the Brownie camera. But during the Alaska-Yukon-Pacific Expo in Seattle, Addie is reunited with Isaac.

Jeffery O'Donnell is captivated by the mysterious Simone, who arrives at his office hoping to acquire a position as a Harvey Girl at the popular way-stops along the frontier rail line. Jeffery is torn, however, when he suspects that Simone may harbor a disturbing secret.

Marty Dandridge Olson is a widow looking for a way out of Texas. Widower Jake Wythe has secured a job as a bank manager in Denver, only to discover that the bank board wants him to be a married man. With Texas in his roots, he advertises for a Lone Star bride, and Marty answers the call. They both agree they are done with romance and love and will make this nothing more than a marriage of convenience. Marty works to carve out a new life in high-society Denver as Jake works to guide the bank through a collapsing economy.

Lillian Porter has always wanted to fulfill her mother's dream of going west, so when she hears about a nanny position in Angels Camp, California, she defies her grandfather and takes a chance on a new future. But she quickly wonders if she made the right choice. There are rumors in town that her new employer, Woodward Colton, caused the death of his wife. This accusation doesn't match the man Lillian comes to know.

For Havyn Powell, growing up on her grandfather Chuck Bondrant's dairy outside the 1904 gold-rush boomtown of Nome, Alaska, offered all she needed. She had the love of her mother, two sisters, and grandfather. But now, at 23, Havyn realizes the stability of her life may soon vanish. Havyn is determined to find a way to keep the family together, but her grandfather's health is declining and everyone seems to be holding secrets from each other, including the handsome, dark-haired stranger who recently arrived.

After her father's death, Lizzy Brookstone, the star trick rider of the all-female Brookstone Wild West Extravaganza, loses interest in performing. Ella Fleming is fleeing a forced engagement when she stows away on the Brookstone train. Lizzy finds her and gives her a job in the costume department. When Mary Reichert, a former sharpshooter for the show, learns that her brother, August, has been killed at the Fleming farm, she returns to the show to find the truth, As the three women work together to discover how August died, Lizzy strives to hold the show together.

Gwen, Beth, and Lacy Gallatin fashion a life for themselves in the Montana wilds, operating a roadhouse that is located at the crossroads of two major stage lines. When their father is accidentally killed, the oldest sister, Gwen, reasons that she's cursed. After all, death seems to haunt her: her mother, now her father...and she was married for a mere ten days before her husband died from a bout of measles.

Emily Carver wants a home where she can put down roots instead of following her gold-hungry father from one mining camp to another. She also longs for tenderness and love, both of which are missing in her life. Yet when she realizes she's losing her heart to the intriguing new man in camp, she fiercely fights her feelings, afraid that love will only result in disappointment and heartache.

On her way to San Francisco to find her brother, Caleb, who went missing three months ago, Camriann Coulter meets Judith and Kenzie, who both have their own mysteries to solve in the booming West Coast city. The women decide to help each other, including rooming together and working at Kenzie's cousin's chocolate factory. Camri's search for her brother, an attorney, leads her deep into the political corruption of the city - and into the acquaintance of Patrick Murdock, a handsome Irishman who was saved from a false murder charge by Caleb.

Driven by desperation, Grace Hawkins must forsake the affluent comfort of her upbringing to save herself from an arranged marriage. Disillusioned by her father's insistence, she forges a daring plan to escape the sinister hand of her intended. Peter Colton sees the Alaskan gold rush as an opportunity to establish his family's fledgling shipping business. An unexpected partnership enables him to pursue those dreams and opens the door to an acquaintance with Grace, who has purchased passage north.

Life's tough on the Montana Territory, especially for the three sisters running the Gallatin Roadhouse - guilt-ridden Gwen, romantic Beth, and headstrong Lacy. Gwen was married at 22, but her husband, Harvey, died 10 days later. When his brother, Hank, turns up looking for stocks he claims Harvey stole, Gwen's perplexed. Will Hank steal her heart?

Faith Kenner is pursuing her dream to become a doctor at Willamette University's medical college so she can use her gift for healing to help those in need, especially the native populations forced onto reservations and then neglected. When she meets Andrew Gratton, a handsome riverboat captain who has been injured on his ship, she uses her skills to tend his wound, and a friendship grows between them. But Faith holds a secret that means their friendship can never become anything more, so she must bury her feelings for Andrew as best she can.