1924. May Marshall is determined to spend the dog days of summer in self-imposed exile at her father’s farm in Keswick, Virginia. Following a naive dalliance that led to heartbreak and her expulsion from Mary Baldwin College, May returns home with a shameful secret only to find her father’s orchard is now the site of a lucrative moonshining enterprise. Despite warnings from the one man she trusts - her childhood friend Byrd - she joins her father’s illegal business. When authorities close in and her father, Henry, is arrested, May goes on the run.

Celebrating her forty-fifth birthday at her local pub, popular podcaster Alix Summer crosses paths with an unassuming woman called Josie Fair. Josie, it turns out, is also celebrating her forty-fifth birthday. They are, in fact, birthday twins. A few days later, Alix and Josie bump into each other again, this time outside Alix’s children’s school. Josie has been listening to Alix’s podcasts and thinks she might be an interesting subject for her series. She is, she tells Alix, on the cusp of great changes in her life.

On a beautiful summer night in a charming English suburb, a young woman and her boyfriend disappear after partying at the massive country estate of a new college friend. One year later, a writer moves into a cottage on the edge of the woods that border the same estate. Known locally as the Dark Place, the dense forest is the writer’s favorite place for long walks and it’s on one such walk that she stumbles upon a mysterious note that simply reads, “DIG HERE.”

Gifted musician Clemency Thompson is playing for tourists on the streets of Southern France when she receives an urgent text message. Her childhood friend, Lucy, is demanding her immediate return to London. It’s happening, says the message. The baby is back. Libby Jones was only six months old when she became an orphan. Now 25, she’s astounded to learn of an inheritance that will change her life. A gorgeous, dilapidated townhouse in one of London’s poshest neighborhoods has been held in a trust for her all these years. Now, it’s hers.

Alice, a novelist, meets Felix, who works in a warehouse, and asks him if he’d like to travel to Rome with her. In Dublin, her best friend, Eileen, is getting over a break-up, and slips back into flirting with Simon, a man she has known since childhood. Alice, Felix, Eileen, and Simon are still young—but life is catching up with them. They desire each other, they delude each other, they get together, they break apart.

Seventeen-year-old Lenni Pettersson lives on the Terminal Ward at the Glasgow Princess Royal Hospital. Though the teenager has been told she’s dying, she still has plenty of living to do. Joining the hospital’s arts and crafts class, she meets the magnificent Margot, an 83-year-old, purple-pajama-wearing, fruitcake-eating rebel, who transforms Lenni in ways she never imagined. As their friendship blooms, a world of stories opens for these unlikely companions who, between them, have been alive for one hundred years.

When she was 9 years old, Melody Browne's house burned down, and it took all of her childhood memories with it. Now she's a single mother of a teenage boy living in Central London. She hasn't seen her parents since she left home at 15, but she doesn't mind. She's better off on her own. She works as a dinner lady at her son's school and has no idea where her humdrum life is heading. But one summer's night, a hypnotist inadvertently unlocks memories of her childhood, and her whole life is turned upside down.

Shuggie’s mother Agnes walks a wayward path: She is Shuggie’s guiding light but a burden for him and his siblings. She dreams of a house with its own front door while she flicks through the pages of the Freemans catalogue, ordering a little happiness on credit, anything to brighten up her grey life. Married to a philandering taxi-driver husband, Agnes keeps her pride by looking good - her beehive, make-up, and pearly-white false teeth offer a glamourous image of a Glaswegian Elizabeth Taylor.

Minnie Cooper knows two things with certainty: that her New Year's birthday is unlucky, and that it's all because of Quinn Hamilton, a man she's never met. Their mothers gave birth to them at the same hospital just after midnight on New Year's Day, but Quinn was given the cash prize for being the first baby born in London in 1990 - and the name Minnie was meant to have, as well. With luck like that, it's no wonder each of her birthdays has been more of a disaster than the one before.

Raised outside of Boston, Ivy’s immigrant grandmother relies on Ivy’s mild appearance for cover as she teaches her granddaughter how to pilfer items from yard sales and second-hand shops. Thieving allows Ivy to accumulate the trappings of a suburban teen - and, most importantly, to attract the attention of Gideon Speyer, the golden boy of a wealthy political family. But when Ivy’s mother discovers her trespasses, punishment is swift and Ivy is sent to China, and her dream instantly evaporates.

Lex Gracie doesn't want to think about her family. She doesn't want to think about growing up in her parents' House of Horrors. And she doesn't want to think about her identity as Girl A: the girl who escaped, the eldest sister who freed her older brother and four younger siblings. It's been easy enough to avoid her parents - her father never made it out of the House of Horrors he created, and her mother spent the rest of her life behind bars. But when her mother dies in prison and leaves Lex and her siblings the family home, she can't run from her past any longer.

When childhood sweethearts Justine (Sagittarius and serious skeptic) and Nick (Aquarius and true believer) bump into each other as adults, a life-changing love affair seems inevitable. To Justine, anyway. Especially when she learns Nick is an astrological devotee, whose decisions are guided by the stars, and more specifically, by the horoscopes in his favorite magazine. The same magazine Justine happens to write for. As Nick continues to not fall headlong in love with her, Justine decides to take Nick’s horoscope, and Fate itself, into her own hands.

"That book. It was about two women, and they fell in love with each other." And then Lily asked the question that had taken root in her, that was even now unfurling its leaves and demanding to be shown the sun: "Have you ever heard of such a thing?" Seventeen-year-old Lily Hu can't remember exactly when the question took root, but the answer was in full bloom the moment she and Kathleen Miller walked under the flashing neon sign of a lesbian bar called the Telegraph Club. America in 1954 is not a safe place for two girls to fall in love, especially not in Chinatown.

Can you ever really know someone? When Deborah, an unpopular 17-year-old, meets the charming and handsome Larry, he sweeps her off her feet. The trouble is, Larry has a secret. Then a series of grisly murders casts a shadow over everything. As Deborah's world starts to fall apart, she begins to suspect the man she loves of a terrible betrayal. And to keep their marriage alive, sacrifices must be made.

Alice Raikes takes a train from London to Scotland to visit her family, but when she gets there she witnesses something so shocking that she insists on returning to London immediately. A few hours later, Alice is lying in a coma after an accident that may or may not have been a suicide attempt. Alice’s family gathers at her bedside and as they wait, argue, and remember, long-buried tensions emerge. The more they talk, the more they seem to conceal. Alice, meanwhile, slides between varying levels of consciousness, recalling her past and a love affair that recently ended.