When a hostage situation turns deadly, Billy loses everything - his wife, his daughter, and his career. Devastated, he heads to Key West to put down his gun and pick up a rod and reel as a fishing boat captain. But former co-worker Roscoe McAuley isn't ready to let Billy rest. When Roscoe tells Billy that someone murdered his son, Billy sends him away.

Evan Smoak is a man with skills, resources, and a personal mission to help those with nowhere else to turn. He’s also a man with a dangerous past. Chosen as a child, he was raised and trained as an Orphan, an off-the-books black box program designed to create the perfect deniable intelligence asset: An assassin. Evan was Orphan X - until he broke with the program and used everything he learned to disappear. But now someone is on his tail.

Jon Reznick is a “ghost”: a black-ops specialist who takes his orders from shadowy handlers, and his salary from the US government. Still mourning the loss of his beloved wife on 9/11, he’s dispatched to carry out a high-level hit. Reznick knows only that it must look like suicide. It’s textbook. But the target is not the man Reznick expected. The whole setup is wrong.

In retreat from a devastating loss and crushing injustice, Katie lives alone in a fortresslike stone house on Jacob’s Ladder island. Once a rising star in the art world, she finds refuge in her painting. The neighboring island of Ringrock houses a secret: a government research facility. And now two agents have arrived on Jacob’s Ladder in search of someone—or something—they refuse to identify. Although an air of menace hangs over these men, an infinitely greater threat has arrived, one so strange even the island animals are in a state of high alarm.

Tommy Miller is a man with deadly skills, hiding in Florida under a false identity. After being set up on an overseas mission, he’s on the run from terrorists—and from the government who betrayed him. So when his wife and daughter are violently abducted, it seems his ghosts are finally catching up with him. But Tommy isn’t the only one with secrets. His wife, Teresa, has been concealing her own dangerous past, and as Tommy races to rescue his family, he must peel away the clues she’s left behind.