The separation from his mother at an early age appears to have left a permanent scar on young Isaac Newton that followed him through the rest of his life. He never married or had any children and had but a few close friends. He would work frantically for days on end, seemingly without food or rest, resting only when the creative spirit left him. However, the work of this ponderous man would have a profound effect on the world as we know it today.

One of the most famous women of the 20th century, Marie Curie was a trailblazer in the truest sense. Known for her discovery of two radioactive elements, radium and polonium, Marie Curie was the first woman to win a Nobel Prize. She remains the only woman to win two Nobel Prizes in different sciences.

Why we think it’s a great listen: You thought he was a stodgy scientist with funny hair, but Isaacson and Hermann reveal an eloquent, intense, and selfless human being who not only shaped science with his theories, but politics and world events in the 20th century as well. Based on the newly released personal letters of Albert Einstein, Walter Isaacson explores how an imaginative, impertinent patent clerk became the mind reader of the creator of the cosmos.

What is autism: a lifelong disability or a naturally occurring form of cognitive difference akin to certain forms of genius? In truth, it is both of these things and more - and the future of our society depends on our understanding it. Wired reporter Steve Silberman unearths the secret history of autism, long suppressed by the same clinicians who became famous for discovering it, and finds surprising answers to the crucial question of why the number of diagnoses has soared in recent years.

Nikola Tesla pursued his ideas for wireless lighting and worldwide wireless electric power distribution in his high-voltage, high-frequency power experiments. Hear more about Tesla in this audiobook.

We know it simply as "the pill", yet its genesis was anything but simple. Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic.

“Doomed from birth” was how psychologist Harold Skeels described two girls at the Orphans’ Home in Davenport, Iowa, in 1934. Following prevailing eugenic beliefs, Skeels and his colleague Marie Skodak assumed that the girls had inherited their parents’ low intelligence and sent them to an institution. To their astonishment, under the women’s care, the children’s IQ scores became normal. Recasting Skeels and his team as intrepid heroes, Marilyn Brookwood weaves years of prodigious archival research to show how after decades of backlash, the Iowans finally prevailed.

Imbeciles is the shocking story of Buck v. Bell, a legal case that challenges our faith in American justice. A gripping courtroom drama, it pits a helpless young woman against powerful scientists, lawyers, and judges who believed that eugenic measures were necessary to save the nation from being “swamped with incompetence.”

Claude Shannon was a tinkerer, a playful wunderkind, a groundbreaking polymath, and a digital pioneer whose insights made the Information Age possible. He constructed fire-breathing trumpets and customized unicycles, outfoxed Vegas casinos, and built juggling robots, but he also wrote the seminal text of the Digital Revolution. That work allowed scientists to measure and manipulate information as objectively as any physical object. His work gave mathematicians and engineers the tools to bring that world to pass.

Creativity is about capturing those moments that make life worth living. Legendary psychologist Mihaly Csikszentmihalyi reveals what leads to these moments - be it the excitement of the artist at the easel or the scientist in the lab - so that this knowledge can be used to enrich people's lives. Drawing on nearly 100 interviews with exceptional people, from biologists and physicists, to politicians and business leaders, to poets and artists, as well as his 30 years of research, Csikszentmihalyi uses his famous flow theory to explore the creative process.

Rabbi Menachem Mendel Schneerson (1902-1994), the Lubavitcher Rebbe, took an insular Chasidic group that was almost decimated by the Holocaust and transformed it into one of the most influential and controversial forces in world Jewry. This superbly crafted biography draws on recently uncovered documents and archives of personal correspondence, painting an exceptionally human and charming portrait of a man who was well known but little understood.

Lee Hood did that rarest of things. He enabled scientists to see things they couldn't see before and do things they hadn't dreamed of doing. Scientists can now sequence complete human genomes in a day, setting in motion a revolution that is personalizing medicine. Hood, a son of the American West, was an unlikely candidate to transform biology. But with ferocious drive, he led a team at Caltech that developed the automated DNA sequencer, the tool that paved the way for the Human Genome Project.

John Forbes Nash, Jr., a prodigy and legend by the age of 30, dazzled the mathematical world by solving a series of deep problems deemed "impossible" by other mathematicians. But at the height of his fame, Nash suffered a catastrophic mental breakdown and began a harrowing descent into insanity, resigning his post at MIT, slipping into a series of bizarre delusions, and eventually becoming a dreamy, ghostlike figure at Princeton, scrawling numerological messages on blackboards.

Enrico Fermi is unquestionably among the greats of the world's physicists, the most famous Italian scientist since Galileo. Called "the Pope" by his peers, he was regarded as infallible in his instincts and research. His discoveries changed our world; they led to weapons of mass destruction and conversely to life-saving medical interventions. This unassuming man struggled with issues relevant today, such as the threat of nuclear annihilation and the relationship of science to politics.

In 1942, a team at the University of Chicago achieved what no one had before: a nuclear chain reaction. At the forefront of this breakthrough stood Enrico Fermi. Straddling the ages of classical physics and quantum mechanics, equally at ease with theory and experiment, Fermi truly was the last man who knew everything - at least about physics. But he was also a complex figure who was a part of both the Italian Fascist Party and the Manhattan Project, and a less-than-ideal father and husband who nevertheless remained one of history's greatest mentors.