From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

Set in the mountains of southern Appalachia, Demon Copperhead is the story of a boy born to a teenaged single mother in a single-wide trailer, with no assets beyond his dead father’s good looks and copper-colored hair, a caustic wit, and a fierce talent for survival. Relayed in his own unsparing voice, Demon braves the modern perils of foster care, child labor, derelict schools, athletic success, addiction, disastrous loves, and crushing losses.

For more than two hundred years, disturbances of the mind—the sorts of things that were once called "madness"—have been studied and treated by the medical profession. Mental illness, some insist, is a disease like any other, whose origins can be identified and from which one can be cured. But is this true? In this masterful account of America's quest to understand and treat everything from anxiety to psychosis, one of the most provocative thinkers writing about psychiatry today sheds light on its tumultuous past.

A diabetic woman awakens from a coma having forgotten the last 10 years of her life. A Haitian immigrant has nightmares that begin bleeding into his waking hours. A retired teacher loses the use of her right hand due to pain of no known origin. Noga Arikha began studying these patients and their confounding symptoms in order to explore how our physical experiences inform our identities. Soon after she initiated her work, the question took on unexpected urgency, as Arikha’s own mother began to show signs of Alzheimer’s disease.

In Life Finds a Way, biologist Andreas Wagner reveals the deep symmetry between innovation in biological evolution and human cultural creativity. Rarely is either a linear climb to perfection - instead, "progress" is typically marked by a sequence of peaks, plateaus, and pitfalls. For instance, in Picasso's 40-some iterations of Guernica, we see the same combination of small steps, incessant reshuffling, and large, almost reckless, leaps that characterize the way evolution transformed a dinosaur's grasping claw into a condor's soaring wing.

Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health.

Many famed music producers are known for a particular sound that has its day. Rick Rubin is known for something else: creating a space where artists of all different genres and traditions can home in on who they really are and what they really offer. He has made a practice of helping people transcend their self-imposed expectations in order to reconnect with a state of innocence from which the surprising becomes inevitable. Over the years, he has learned that being an artist isn’t about your specific output, it’s about your relationship to the world.

This magnificent novel - which secured for its author the 1955 Nobel Prize in Literature - is now available to contemporary American audiences. Although it is set in the early 20th century, it recalls both Iceland's medieval epics and such classics as Sigrid Undset's Kristin Lavransdatter. And if Bjartur of Summerhouses, the book's protagonist, is an ordinary sheep farmer, his flinty determination to achieve independence is genuinely heroic and, at the same time, terrifying and bleakly comic.

How does the brain—a three-pound wrinkly mass—give rise to intelligence and conscious experience? Was Freud right that we are all plagued by forbidden sexual desires? What is the function of emotions such as disgust, gratitude, and shame? Renowned psychologist Paul Bloom answers these questions and many more in Psych, his riveting new book about the science of the mind.

Few journalists working today have covered Donald Trump more extensively than Maggie Haberman. And few understand him and his motivations better. Now, demonstrating her majestic command of this story, Haberman reveals in full the depth of her understanding of the 45th president himself, and of what the Trump phenomenon means.

We feel, therefore we are. Conscious sensations ground our sense of self. They are crucial to our idea of ourselves as psychic beings: present, existent, and mattering. But is it only humans who feel this way? Do other animals? Will future machines? Weaving together intellectual adventure and cutting-edge science, Nicholas Humphrey describes in Sentience his quest for answers: from his discovery of blindsight in monkeys and his pioneering work on social intelligence to breakthroughs in the philosophy of mind.

This pioneering account sets out to understand the structure of the human brain - the place where mind meets matter. Until recently, the left hemisphere of our brain has been seen as the "rational" side, the superior partner to the right. But is this distinction true? Drawing on a vast body of experimental research, Iain McGilchrist argues while our left brain makes for a wonderful servant, it is a very poor master.

The millions of people around the world who loved What If? still have questions, and those questions are getting stranger. Thank goodness xkcd creator Randall Munroe is here to help. Planning to ride a fire pole from the Moon back to Earth? The hardest part is sticking the landing. Hoping to cool the atmosphere by opening everyone’s freezer door at the same time? Maybe it’s time for a brief introduction to thermodynamics. Want to know what would happen if you rode a helicopter blade, made a lava lamp out of lava, or jumped on an erupting geyser? Okay, if you insist.

Dylan, who began working on the book in 2010, offers his insight into the nature of popular music. He writes over sixty essays focusing on songs by other artists, spanning from Stephen Foster to Elvis Costello, and in between ranging from Hank Williams to Nina Simone. He analyzes what he calls the trap of easy rhymes, breaks down how the addition of a single syllable can diminish a song, and even explains how bluegrass relates to heavy metal. These essays are written in Dylan’s unique prose. And while ostensibly about music, they are really meditations on the human condition.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.