Thirty years after the Great Fatigue infected the globe—and the treatment regressed most of the human race to a primitive state—Seth Keller makes a gruesome discovery in his adoptive father’s makeshift lab. This revelation forces him to leave the safety of his desert home and the only other person left in the world…at least, as far as he knows. In the jungles of Costa Rica, Sarah Peoples has made her own discovery—just as horrific, and just as life-changing. It will take her far from the fledgling colony of New Haven, yet never out of reach of its ruthless leader.

In 2030, a grieving archeologist arrives in the Arctic Circle to continue the work of his recently deceased daughter at the Batagaika Crater, where researchers are studying long-buried secrets now revealed in melting permafrost, including the perfectly preserved remains of a girl who appears to have died of an ancient virus. Once unleashed, the Arctic plague will reshape life on Earth for generations to come, quickly traversing the globe, forcing humanity to devise a myriad of moving and inventive ways to embrace possibility in the face of tragedy.

In the first decades of the 21st century, the world is convulsing, its governments mired in gridlock while a patient but unrelenting ecological crisis looms. America is in upheaval, battered by violent weather and extreme politics. In California in 2013, Tony Pietrus, a scientist studying deposits of undersea methane, receives a death threat.

The Pandominion: a political and trading alliance of a million worlds–except that they’re really just the one world, Earth, in many different realities. And when an AI threat arises that could destroy everything the Pandominion has built, they'll eradicate it by whatever means necessary, no matter the cost to human life.

The Barnes family is in trouble. Dickie’s once-lucrative car business is going under—but Dickie is spending his days in the woods, building an apocalypse-proof bunker with a renegade handyman. His wife, Imelda, is selling off her jewelry on eBay and half-heartedly dodging the attention of fast-talking cattle farmer Big Mike, while their teenage daughter, Cass, formerly top of her class, seems determined to binge drink her way through her final exams. As for twelve-year-old PJ, he’s on the brink of running away.

A smog has spread. Food crops are rapidly disappearing. A chef escapes her dying career in a dreary city to take a job at a decadent mountaintop colony seemingly free of the world’s troubles. There, the sky is clear again. Rare ingredients abound. Her enigmatic employer and his visionary daughter have built a lush new life for the global elite, one that reawakens the chef to the pleasures of taste, touch, and her own body.

Hig survived the flu that killed everyone he knows. His wife is gone, his friends are dead, he lives in the hangar of a small abandoned airport with his dog, his only neighbor a gun-toting misanthrope. In his 1956 Cessna, Hig flies the perimeter of the airfield or sneaks off to the mountains to fish and to pretend that things are the way they used to be. But when a random transmission somehow beams through his radio, the voice ignites a hope deep inside him that a better life exists beyond the airport.

Sleepwalk’s hero, Will Bear, is a man with so many aliases that he simply thinks of himself as the Barely Blur. At 50 years old, he’s been living off the grid for over half his life. He’s never had a real job, never paid taxes, never been in a committed relationship.

Edgar Hill is 35 and caught in his own headlock. Overweight slob, underperforming husband, and reluctant father - for Ed, the world may as well have already ended. So when it does end in a catastrophic asteroid strike and Edgar and his family find refuge in an Edinburgh army barracks, it comes as something of a relief. But nothing's ever that simple. Returning from a salvage run in the city, Edgar finds his family gone, taken to the south coast for evacuation by an international task force.

At first, Logan Ramsay isn’t sure if anything’s different. He just feels a little . . . sharper. Better able to concentrate. Better at multitasking. Reading a bit faster, memorizing better, needing less sleep. But before long, he can’t deny it: Something’s happening to his brain. To his body. He’s starting to see the world, and those around him—even those he loves most—in whole new ways. The truth is, Logan’s genome has been hacked. And there’s a reason he’s been targeted for this upgrade.

Coco Wells hasn’t seen another living person since she was a teenager. All of Manhattan is reliving the same few seconds, minutes, or hours on a loop…and they have been for years. Everything looks normal from a distance, but up close, it’s a nightmare.

All magic comes with a price, though, and for years the sisters have been separated. Esther has fled to a remote base in Antarctica to escape the fate that killed her own mother, and Joanna’s isolated herself in their family home in Vermont, devoting her life to the study of these cherished volumes. But after their father dies suddenly while reading a book Joanna has never seen before, the sisters must reunite to preserve their family legacy.

Twelve-year-old Bird Gardner lives a quiet existence with his loving father, a former linguist who now shelves books in a university library. His mother, Margaret, a Chinese American poet, left without a trace when he was nine years old. He doesn’t know what happened to her—only that her books have been banned—and he resents that she cared more about her work than about him.

Franny Stone has always been the kind of woman who is able to love but unable to stay. Leaving behind everything but her research gear, she arrives in Greenland with a singular purpose: to follow the last Arctic terns in the world on what might be their final migration to Antarctica. Franny talks her way onto a fishing boat, and she and the crew set sail, traveling ever further from shore and safety. But as Franny’s history begins to unspool - a passionate love affair, an absent family, a devastating crime - it becomes clear that she is chasing more than just the birds.

Born a generation apart and with very different ideas about love and family, Mariam and Laila are two women brought jarringly together by war, by loss, and by fate. As they endure the ever escalating dangers around them, in their home as well as in the streets of Kabul, they come to form a bond that makes them both sisters and mother-daughter to each other, and that will ultimately alter the course not just of their own lives but of the next generation.