Today, we will analyze the Abstract of an impressive paper. It is the paper that led to the 2023 Nobel Prize in Physiology or Medicine. This is the paper that we call the milestone article 1.

We will have two essential pre-analysis sub-steps, and then we will analyze each sentence. During this analysis, we will read each sentence of the Abstract, examine the role of each sentence, and assign each sentence to a structural component, so that we will be able to understand the authors’ intention for each sentence.

Here are two sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.

Milestone Article 1:

• “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005.
• DOI: https://doi.org/10.1016/j.immuni.2005.06.008
• PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf
• PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/

Copyright of the paper (as of March, 2025):

• See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it).
• Check the “User License” section which lists the “Elsevier user license”:
• --- http://www.elsevier.com/open-access/userlicense/1.0/
• --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user

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