After 12 days of war between Israel and Iran, a ceasefire has brought a sense of cautious relief to the region.

Even after almost 21 months of war in Gaza and its spillover into neighbouring countries, the latest escalation set a dangerous precedent that could provoke more cycles of warfare and destabilise the Middle East.

The question is how did we reach this boiling point? The answer goes back decades, to a time even before the 1979 revolution in Iran when the country enjoyed a more co-operative relationship with Israel under the shah.

At the same time the region was going through a transformative period against the backdrop of the 1967 Arab-Israeli war and rising anti-imperialist sentiments. As events unfolded and political leaderships changed over time, so did the strategic interests that Israel shared with Iran.

In this episode of Beyond the Headlines, host Nada AlTaher dives into the context that soured the relationship between the two countries, and the more recent events that brought about the air war.

She is joined by The National's assistant foreign editor Aveen Karim, senior fellow at UCLA Burkle Centre for International Relations Dalia Dassa Kaye, and independent Israeli analyst Ori Goldberg.

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Up until last week, it seemed unthinkable for a UN member state to strike a nuclear site. But Israel did just that when it launched its attack on Iran, hitting military and atomic sites, and killing key figures of the Islamic Revolutionary Guard Corps.

It also seemed unthinkable for missiles to penetrate Israel’s Iron Dome and destroy infrastructure in cities such as Haifa and Tel Aviv.

Yet again, civilians are paying the heaviest price. More than 240 people have been killed in Iran so far. In Israel, at least 24 people have been killed in retaliatory strikes. One week on, the war shows no signs of abating, with the US hinting it might get involved, too.

A sense of unease has gripped the region, with neighbouring states fearing further escalation. A group of 20 countries including Gulf states, Jordan and Egypt has called for an end to hostilities. In a worst-case scenario, the repercussions could be catastrophic for them, too.

In this episode of Beyond the Headlines, host Nada AlTaher looks at the consequences of the war on the Middle East and asks what will happen to the region if Tehran were to fall? She speaks to Hasan AlHasan, senior fellow for Middle East policy at the International Institute for Strategic Studies, and Thomas Juneau, Middle East researcher and a professor at University of Ottawa, Canada.

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Canada, urging de-escalation of the conflict between Iran and Israel, but US President Donald Trump has already left, having warned that residents of Tehran "should immediately evacuate".

Iran's reaction is one of the key issues on the agenda today.

In this special episode of Beyond the Headlines, Geo-Economics Editor Manus Cranny asks Mina Al-Oraibi, Editor-in-Chief, and Mohamad Ali Harisi, Foreign Editor, for the inside view.