In this week’s episode of the BroadEYE Podcast, hosts Dr. Shawn Maloney and Dr. Carlos Quezada-Ruiz sit down with Dr. Wiley Chambers, recently retired Deputy Director of the Division of Ophthalmology at the U.S. Food and Drug Administration (FDA). With over 36 years at the FDA, Dr. Chambers offers a rare insider’s perspective on regulatory science, ophthalmic drug development, and the evolution of clinical trial oversight.

This episode explores:

• How ophthalmology regulation has changed over the decades
• Common pitfalls in pre-IND meetings and what smart innovators do differently
• Lessons learned from reviewing countless drug and biologic applications
• The future of FDA guidance in areas like rare disease, gene therapy, and digital endpoints

Dr. Chambers also shares personal reflections on mentorship, scientific integrity, and his transition out of federal service after a distinguished career.

About Our Guest Dr. Wiley Chambers served as a lead ophthalmic reviewer at the U.S. FDA from 1987 until his retirement in 2023. As Deputy Director of the Division of Ophthal

In this episode of the BroadEYE Podcast, we welcome inventor, researcher, and MacArthur Fellow Dr. Joshua Miele. Known for his pioneering work in accessible technology for blind users, Dr. Miele shares his journey from early advocacy to his role at Amazon’s Lab126, where he continues to develop tools that redefine independence and equity in the built and digital worlds.

Explore Dr. Joshua Miele’s work, projects, and writings on his personal site, MieleLab, which highlights his innovations in accessible design and disability inclusion. You can visit it here: www.mielelab.com

Joining as co-host is Victoria Nolan—a decorated Paralympian, accessibility advocate, and BroadEYE regular. With lived experience navigating vision loss, Victoria brings deep empathy and clarity to the discussion, drawing out the personal and systemic forces that shape accessibility work today.

Together, they explore:

• The real meaning of inclusion, and why accessibility must be baked in—not bolted on.

• Dr. Miele’s development of tactile maps, screen readers, and accessible media interfaces.

• How institutions can move from compliance to genuine cultural transformation.

Dr. Miele also reflects on the resilience required to challenge ableist assumptions and the power of disabled leadership in tech innovation. His message is clear: access is not about charity—it’s about justice.

About Our Guests

Dr. Joshua Miele is a blind scientist, designer, and advocate for accessibility. Currently a Principal Accessibility Researcher at Amazon, he has developed technologies that empower blind and visually impaired people to navigate cities, classrooms, and digital spaces. He is a 2021 MacArthur “Genius Grant” recipient and a prominent voice for disability rights and design justice.

Want to learn more? Pick up Dr. Miele’s powerful memoir, “Connecting the Dots: From the Blind Side”, now available on Amazon.

Victoria Nolan is a Canadian Paralympic rower, author, and passionate advocate for inclusion. Diagnosed with retinitis pigmentosa in her youth, she went on to compete internationally in rowing, including two Paralympic Games. Today, she is an influential public speaker and ambassador for breaking down barriers for people with vision loss.

In this episode of the BroadEYE Podcast, host Sean Maloney is joined by guest co-host Dr. Carlos Quezada-Ruiz for a deep and inspiring conversation with Dr. Margaret Chang, one of the leading figures in retina research and innovation.

From the start, Dr. Quezada-Ruiz sets the tone, describing Dr. Chang as not only a scientific leader but also a mentor, friend, and advocate for meaningful innovation. Their conversation ranges from early inspirations and pivotal career decisions to her ongoing efforts in bridging clinical research and real-world impact.

Dr. Chang shares candid thoughts on what drives her work at the intersection of patient care and technology, how she evaluates opportunities in translational research, and what keeps her motivated in the ever-evolving field of retina. Her reflections offer a rare glimpse into the mindset of a researcher who blends vision, rigor, and humility.

Whether you're a clinician, student, or someone curious about the future of ophthalmology, this episode offers both inspiration and actionable insight.

About Our Guest Dr. Margaret Chang is an internationally recognized retina specialist and researcher. With a career spanning academia, clinical practice, and biotech innovation, she is known for her leadership in translating science into practice. A sought-after speaker and advisor, Dr. Chang continues to influence the field through both groundbreaking research and mentorship.