Katie traveled to Washington, D.C. to sit down with Jake Tapper and Alex Thompson for a candid conversation about their book Original Sin—an investigation into how President Biden’s decline was hidden from voters, colleagues, and even some members of the press. As questions swirl in the wake of his cancer diagnosis, their reporting offers critical insight into just how long this story has been building. They discuss the blind spots that shaped media coverage, the role of Biden’s inner circle, and how silence and loyalty collided in the final year of his presidency.

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They weren’t political operatives—they were a civil rights lawyer, a digital editor, and a marketing guy. But in the chaos of the Trump era, the Meiselas Brothers felt compelled to act. In their first in-person interview all together, Katie gets the behind-the-scenes story of how a pandemic group chat turned into the ascendent progressive MeidasTouch Network, and why truth, clarity, and community—not partisanship—are at the heart of what they do.

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New York Times reporter Astead Herndon has spent years embedded in the world of Trump voters. He joins Katie to explain what he’s hearing now—why economic fear, media distrust, and cultural resentment still fuel Trumpism, how tariffs and Elon Musk are playing with the base, and why the Democrats’ message just isn’t landing. If you think you know what’s driving voters in 2024, think again

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"Microbiome" is a buzzword these days--but many people don't know what it means. As we re-assess the lasting impact diet may have on our health, researchers are examining the role of gut health as possible causes for the dramatic uptick in colorectal cancer in young people. Katie Couric, founder of Katie Couric Media and Stand Up To Cancer, hosts an expert-led panel including Dr. Nancy You, a surgeon and director of the Young-Onset Colorectal Cancer Program at MD Anderson, Dr. Susan Bullman–an Associate Professor of Gastrointestinal Medical Oncology at The University of Texas MD Anderson Cancer Center, and Julie Smolyansky, CEO of Lifeway Foods, to discuss the impact of diet on the gut microbiome.

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Trump’s first 100 days? Worse than former congressman and “proud RINO” Adam Kinzinger ever imagined. He joins Katie for a bracing conversation about authoritarian creep, advice on Democratic Party messaging, why the next few years could be rougher than anyone’s ready for–and why blind optimism is useless, but keeping hope alive can galvanize the American people.

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In this heartfelt conversation, Katie sits down with the iconic Christie Brinkley or an intimate look at the moments that shaped her–from her bohemian days in Paris to the glitz of Studio 54, from the heights of modeling fame to unexpected heartbreak. With warmth, candor, and even a little singing, Christie opens up about a life lived in full technicolor--and now finally captured in her new memoir, Uptown Girl

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Project 2025. Maybe you’ve heard whispers about it. Maybe you’ve rolled your eyes. But David A. Graham read the whole thing—and he sat down with Katie to break down why this isn’t just rhetoric – it’s a roadmap already in motion. From privatizing weather data to rewinding civil rights gains, this playbook for Trump 2.0 is more extreme—and more possible—than you might think. In this episode, Graham walks us through the wildest parts of the plan, the men behind it, and why his book The Project might just be the most important one you read this year.

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Today, approximately 10,000 rare diseases collectively affect as many as 400 million people around the world, and women leaders have long been at the forefront of bringing awareness to these diseases and driving change. Katie Couric moderates a panel that includes Tania Simoncelli of Chan Zuckerberg Initiative, whose “Rare as One” campaign gives to rare disease researchers and support groups, Tara Zier who founded the Stiff Person Syndrome Research Foundation, Susan Dando of the Smith-Kingsmore Syndrome Foundation, and Dr. Christina Miyake, a researcher studying TANGO2 deficiency disorder. This panel will explore the resilience, determination, and ingenuity required to address the unique challenges in rare disease advocacy and research. Panelists will share their experiences in breaking barriers, leading patient-centered initiatives, and building collaborations that move the needle toward treatments and cures. #SponsoredbyCZI

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