Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases

Ms Melody Zuo, Dr Le Chang and Professor Sarah A Gagliano Taliun grace the Brain podcast with an insightful discussion into their recent review examining the connection between kidney disease and neurogeneration. They describe the critical microvascular connection as well as the role of uraemia and small molecules like erythropoetin. Additonally, methodological issues around survival bias, the use of mendelial randomisation and the importance of metadata in the growing age of large available datasets.

Check out the full article on the Brain website and will be part of the August 2025 issue: https://doi.org/10.1093/brain/awaf113

This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 27th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Lucia M Li of the Brain article entitled: High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury

Listen to the fascinating insights into classifying traumatic brain injury (TBI) using high dimensional proteomic analysis. TBI may start with a head injury but evidence suggests that multiple different underlying pathophysiological pathways can emerge thereafter. Dr Li also describes how she envisages the future of TBI assessment and potential management.

Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae305

This episode was co-hosted, edited and produced by David Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure

This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may be more influx but not efflux associated with reduced ejection fraction. This has interesting implications on heart failure associated cognitive changes and risk of developing dementia.

Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae411

This episode was co-hosted, edited and produced by Xin You Tai and Roberto Bellanti, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.