What if everything you thought you knew about weight management was wrong? Dr. Alexandra Sowa, board-certified internist and obesity medicine specialist, challenges conventional wisdom in this eye-opening conversation about the true nature of obesity and the revolutionary medications transforming its treatment.

This episode is sponsored by Rio.life who makes GLP-1 agonists available in their programs. I am an advisor to Rio but I only advise companies that I believe in and would use for myself and my family.

The standard advice of "eat less, exercise more" has failed generations of patients because it fundamentally misunderstands obesity as a willpower problem rather than what it truly is—a disease of neurohormonal dysregulation. Our modern environment, particularly our food system, has damaged the delicate balance between our brains and hormones, making sustainable weight management virtually impossible for most people through behavioral changes alone.

Enter GLP-1 medications like Ozempic, Wegovy, and Mounjaro. These synthetic versions of hormones our bodies naturally produce are revolutionizing treatment by addressing the underlying dysfunction. Working throughout the body—in the brain, stomach, and pancreas—they reset hormonal signals, reduce inflammation, and stabilize blood sugar. Perhaps most remarkably, they transform food cravings at the genetic level, making healthy choices feel natural rather than punishing.

The benefits extend far beyond weight loss. Recent studies show these medications can prevent heart attacks and strokes, slow dementia progression, treat sleep apnea, and even help with addiction disorders. Dr. Sowa calls them "longevity medications" with potential to add healthy years to patients' lives by reducing systemic inflammation and improving metabolic health.

Ready to understand the science behind today's most talked-about medications and their potential to transform not just individual health but society's approach to metabolic disease? This conversation offers both practical guidance for patients and a vision for how we might reimagine our relationship with food, weight, and health.

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