Medical Biology

Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-19th century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately - childbed fever in Vienna all but disappeared - they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

Scientists and genetic engineers are becoming increasingly adept at editing the human genome. How far can—and should—they go in editing future generations? In The Promise and Peril of CRISPR, editor Neal Baer brings together a timely collection of essays by influential bioethicists, philosophers, and geneticists to explore the moral, ethical, and policy challenges posed by CRISPR technology.

Important and provocative, The Undead examines why even with the tools of advanced technology, what we think of as life and death, consciousness and nonconsciousness, is not exactly clear - and how this problem has been further complicated by the business of organ harvesting.

Scientists have long struggled to make pregnancy easier, safer, and more successful. In The Dance of Life, developmental and stem-cell biologist Magdalena Zernicka-Goetz takes us to the front lines of efforts to understand the creation of a human life. She has spent two decades unraveling the mysteries of development, as a simple fertilized egg becomes a complex human being of 40 trillion cells. Zernicka-Goetz's work is both incredibly practical and astonishingly vast.

College sophomore Felicia Monroe has just made the biggest mistake of her life. While babysitting her neighbors' three-year-old son, she let her guard down...and he ran out of the house and down the street! Well, the boy's parents went ballistic on Felicia for her irresponsibility. One week later, the father tells Felicia that he has found a way for her to make it up to him. He needs a medical model for a biology class at the college she attends, and his regular model is unavailable. That means getting her clothes off to be posed and examined in front of a bunch of medical students!

Since the dawn of humankind, mental illness has been one of our greatest causes of suffering as a species. But for the majority of our history, its causes have remained a mystery. Professor Karl Deisseroth shares his breakthrough discovery, optogenetics, a biological technique that allows us to decipher the brain's inner workings using light. With moving and revelatory stories from both personal and professional experience, he reveals what mental illnesses really are, why we suffer from them and the unexpected role they have played in our evolution.

Carl Zimmer investigates one of the biggest questions of all: what is life? The answer seems obvious until you try to seriously answer it. Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can’t answer that question here on Earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society’s most charged conflicts - whether a fertilised egg is a living person, for example, and when we ought to declare a person legally dead.

With trusted expertise from Mayo Clinic, the Edge of Medicine series sets out to inspire and educate the next generation of young scientists by highlighting the medical breakthroughs of a diverse range of scientists and researchers. From the discovery of the double helix to mapping the human genome, this exploration of scientific inquiry celebrates the greatest developments to date in genetics. Get to know the physicians, scientists, and other researchers responsible for these breakthroughs in medicine, and explore the ups, the downs, and the eureka moments that are science in action.

Dr Jonathan Reisman - physician, adventure traveller and naturalist - allows listeners to navigate their insides like an explorer discovering a new world. Through his offbeat adventures in healthcare and travel, Reisman discovers new perspectives on the body: a trip to the Alaskan Arctic reveals that fat is not the enemy, but the hero; a stint in the Himalayas uncovers the boundary where the brain ends and the mind begins; and eating a sheep's head in Iceland offers a lesson in empathy.

From the stethoscope to the clinical trial, this exploration of scientific inquiry celebrates the greatest inventions in medicine. Get to know the physicians, scientists, and other researchers responsible for these breakthroughs in medicine, and explore the ups, the downs, and the eureka moments that are science in action.