The struggle to perform well is universal: each one of us faces fatigue, limited resources, and imperfect abilities in whatever we do. But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In this book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable.

A month before her death on May 20, 1989, Gilda Radner entered a Los Angeles recording studio to deliver what would be her final performance - this remarkable audio autobiography, in which she reveals the inspirational story of her struggle with cancer...a private, personal battle in which the humor and humanity that has touched millions became her most powerful weapon.

Part inspirational cancer-survival story, part memoir-as-laugh-riot, Fran Drescher's new book picks up where Enter Whining left off. After her marriage ended, her TV series was cancelled, and her beloved dog died, Fran started having symptoms no doctor could adequately explain. With her trademark humor, she tells of her tireless search for answers and the cancer diagnosis that she ultimately beat.

One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose of­fice she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.

At the age of thirty-six, on the verge of completing a decade’s worth of training as a neurosurgeon, Paul Kalanithi was diagnosed with stage IV lung cancer. One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

In the summer after graduating from college, Suleika Jaouad was preparing, as they say in commencement speeches, to enter “the real world”. She had fallen in love and moved to Paris to pursue her dream of becoming a war correspondent. The real world she found, however, would take her into a very different kind of conflict zone. It started with an itch - first on her feet, then up her legs, like a thousand invisible mosquito bites. Then a trip to the doctor and, a few weeks shy of her 23rd birthday, a diagnosis: leukemia, with a 35 percent chance of survival.

Dr. Jamison is one of the foremost authorities on manic-depressive (bipolar) illness; she has also experienced it firsthand. For even while she was pursuing her career in academic medicine, Jamison found herself succumbing to the same exhilarating highs and catastrophic depressions that afflicted many of her patients, as her disorder launched her into ruinous spending sprees, episodes of violence, and an attempted suicide.

Happiness begins with a charming courtship between hopelessly attracted opposites: Heather, a world-roaming California girl, and Brian, an intellectual, homebody writer, kind and slyly funny, but loath to leave his Upper West Side studio. Their magical interlude ends, full stop, when Heather becomes pregnant - Brian is sure he loves her, only he doesn't want kids. Heather returns to California to deliver their daughter alone, buoyed by family and friends.

In September 1998, Michael J. Fox stunned the world by announcing he had been diagnosed with Parkinson's disease: a degenerative neurological condition. In fact, he had been secretly fighting it for seven years. The worldwide response was staggering. Fortunately, he had accepted the diagnosis and by the time the public started grieving for him, he had stopped grieving for himself.

It’s hard to give up on the feeling that the life you really want is just out of reach. A beach body by summer. A trip to Disneyland around the corner. A promotion on the horizon. Everyone wants to believe that they are headed toward good, better, best. But what happens when the life you hoped for is put on hold indefinitely?

When 24-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she’d gotten there. Days earlier, she had been on the threshold of a new, adult life: At the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?

Los Angeles, 1920s: Socialite Mirielle West's days are crowded with shopping, luncheons, and prepping for the myriad glittering parties she attends with her actor husband, Charlie. She's been too busy to even notice the small patch of pale skin on the back of her hand. Other than an occasional overindulgence in gin and champagne, which helps to numb the pain of recent tragedy, Mirielle is the picture of health. But her doctor insists on more tests, and Mirielle reluctantly agrees. The diagnosis - leprosy - is devastating and unthinkable.

Eleven-year-old Anna has lived all her life with severe epilepsy. Despite the ravage of thousands of violent seizures and heavy medications, she has thrived at school, athletics, and her greatest passion—dance. As she approaches her twelfth birthday, Anna's condition takes a dire turn. Her health declines quickly and a new diagnosis is revealed, leaving the family only one excruciating choice.

Amy Bloom began to notice changes in her husband, Brian: He retired early from a new job he loved; he withdrew from close friendships; he talked mostly about the past. Suddenly, it seemed there was a glass wall between them, and their long walks and talks stopped. Their world was altered forever when an MRI confirmed what they could no longer ignore: Brian had Alzheimer’s disease.

Julia Fox Garrison refused to listen to the professionals she called Dr. Jerk and Dr. Panic, who - after she suffered a massive, debilitating stroke at age thirty-seven - told her she’d probably die, or to Nurse Doom, who ignored her emergency call button. Instead she heeded the advice of kind, gifted Dr. Neuro, who promised her he would “treat your mind as well as your body.” Julia figured if she could somehow manage to get herself into a wheelchair, at least she’d always find parking. But after many, many months of hospitalization and rehab, Julia not only got into a wheelchair, but she got back out.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

"Okay, Lord, you can have him. But if he must die, I want it to be for something big. I want someone’s life to be changed forever." This is what Laura Sobeich prayed when she found out her 17-year-old son had only one year to live. With this desperate prayer, she released her son to God’s will. At that point, Zach Sobiech was just another teenager battling cancer. When his mother told him to think about writing good-bye letters to family and friends, he decided instead to write songs. One of them, "Clouds", captured hearts and changed not one life but millions, making him an international sensation.

His name was Joshua Silver. He was 23 years old, educated, and had an impressive vocabulary. The NYPD had found Joshua Silver naked in Times Square, barking like a dog. It was just another night for Julie Holland, the attending doctor in the world famous Bellevue Hospital's psychiatric emergency room.

101 True Stories about how Positive Thinking can change your life! Everyone needs a little attitude adjustment once in a while, and these amazing true life stories reveal how real people used positive thinking to improve their lives and overcome challenges. You’ll read stories about how you can make every day a special day, incorporate gratitude and joy into your daily life, count your blessings and change your outlook, use a few well-chosen words to reorient your life, manage cancer and other health challenges through a positive attitude, simplify and have a more meaningful life and more!

The unforgettable inspiring memoir of one extraordinary doctor who is saving lives in a most unconventional way, Ask Me Why I Hurt is the touching and revealing first-person account of the remarkable work of Dr. Randy Christensen. Trained as a pediatrician, he works not in a typical hospital setting but, rather, in a 38-foot Winnebago that has been refitted as a doctor's office on wheels. His patients are the city's homeless adolescents and children.

Oprah Winfrey has called him an inspiration, Maya Angelou saw him as a kindred spirit and fellow poet, and Jimmy Carter described Mattie Stepanek as the "most remarkable person I have ever known". When Jerry Lewis received his lifetime achievement award at the Oscars, footage of Mattie played behind him. Five years after his death from a rare neuromuscular disease, Mattie is still being celebrated for his indomitable spirit and message of hope.

People often say, "I feel like I've been run over by a truck." Katie actually was. On a sunny morning bike ride in Brooklyn, 24-year-old Katie McKenna was forever changed when she was run over by an 18-wheeler. Being crushed under a massive semi wasn't something Katie should have survived. After 10 hours of emergency surgery, she woke to find herself in a body and a life that would never be the same.

Clare Dunkle seemed to have an ideal life - two beautiful, high-achieving teenage daughters, a loving husband, and a satisfying and successful career as a children's book novelist. But it's when you let down your guard that the ax falls. Just after one daughter successfully conquered her depression, another daughter developed a life-threatening eating disorder.

At first, Ken Abraham wrote off his mother’s changes in behavior as quirks that just come with old age. There was memory loss, physical decline, hygiene issues, paranoia, and uncharacteristic attitudes. He soon realized that dementia had changed her life - and his family’s - forever. According to the Alzheimer’s Association, an estimated 5.4 million Americans of all ages have Alzheimer’s disease. That’s one in eight older Americans. More than likely, that figure includes someone you know and love.

Ghostbelly is Elizabeth Heineman’s personal account of a home birth that goes tragically wrong—ending in a stillbirth—and the harrowing process of grief and questioning that follows. It’s also Heineman’s unexpected tale of the loss of a newborn: before burial, she brings the baby home for overnight stays.

At the beginning of his physical transition from female to male, then-17-year-old Skylar Kergil posted his first video on YouTube. In the months and years that followed, he recorded weekly update videos about the physical and emotional changes he experienced. Skylar’s openness and positivity attracted thousands of viewers, who followed along as his voice deepened and his body changed shape. Through surgeries and recovery, highs and lows, from high school to college to the real world, Skylar welcomed others on his journey.

Dr. Kathy Magliato is one of fewer than a dozen female heart surgeons practicing in the world today. She is also a member of an even more exclusive group - those surgeons who perform heart transplants. Healing Hearts is the story of the making of a surgeon who also calls herself a wife and mother.

Thirty-four-year-old Rebecca Alexander is a psychotherapist, a spin instructor, a volunteer, and an athlete. She is also almost completely blind, with significantly deteriorated hearing. Not Fade Away is a deeply moving exploration of the obstacles we all face-physical, psychological, and philosophical. Rebecca's story is an exquisite reminder to live each day to its fullest.

When unexpected grief brings two families together, how do they start their journey to healing? Join Michael and Gina Spehn--bestselling authors and founders of the New Day Foundation--as they tell their story of resilience, remembrance, and reliance on their shared faith.