"The dead can't hurt you. Only the living can." Effie Jones, a former slave who escaped to the Union side as a child, knows the truth of her words. Taken in by an army surgeon and his wife during the War, she learned to read and write, to tolerate the sight of blood and broken bodies - and to forget what is too painful to bear. Now a young freedwoman, she has returned south to New Orleans and earns her living as an embalmer, her steady hand and skillful incisions compensating for her white employer's shortcomings.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

Once a trailblazer in the field of medicine, Dr. Tucia Hatherley hasn't touched a scalpel or stethoscope since she made a fatal mistake in the operating theater. Instead, she works in a corset factory, striving to earn enough to support her disabled son. When even that livelihood is threatened, Tucia is left with one option-to join a wily, charismatic showman named Huey and become part of his traveling medicine show.

Los Angeles, 1920s: Socialite Mirielle West's days are crowded with shopping, luncheons, and prepping for the myriad glittering parties she attends with her actor husband, Charlie. She's been too busy to even notice the small patch of pale skin on the back of her hand. Other than an occasional overindulgence in gin and champagne, which helps to numb the pain of recent tragedy, Mirielle is the picture of health. But her doctor insists on more tests, and Mirielle reluctantly agrees. The diagnosis - leprosy - is devastating and unthinkable.

Eleven-year-old Grace Carter has a talent for hiding things. She's had plenty of practice, burying thoughts and feelings that might anger her strict evangelical pastor father. The Knowing, as Grace calls it, offers glimpses of people's pasts and futures. It enables her to see into the depth of her mother's sadness, and even allows Grace to talk to Isaac, her twin brother who died at birth. To her wise, loving Aunt Pearl, the Knowing is a family gift; to her daddy, it's close to witchcraft.

For 14-year-old Wallis Ann Stamper and her family, life in the Appalachian Mountains is simple and satisfying, though not for the tenderhearted. While her older sister, Laci - a mute, musically gifted savant - is constantly watched over and protected, Wallis Ann is as practical and sturdy as her name. When the Tuckasegee River bursts its banks, forcing them to flee in the middle of the night, those qualities save her life. But though her family is eventually reunited, the tragedy opens Wallis Ann's eyes to a world beyond the creek that's borne their name for generations.

On a summer evening in 1931, Lilly Blackwood glimpses circus lights from the grimy window of her attic bedroom. Lilly isn't allowed to explore the meadows around Blackwood Manor. She's never even ventured beyond her narrow room. Momma insists it's for Lilly's own protection, that people would be afraid if they saw her. But on this unforgettable night, Lilly is taken outside for the first time - and sold to the circus sideshow.

In early 1943, Magda Ritter's parents send her to relatives in Bavaria, hoping to keep her safe from the Allied bombs strafing Berlin. Young German women are expected to do their duty - working for the Reich or marrying to produce strong, healthy children. After an interview with the civil service, Magda is assigned to the Berghof, Hitler's mountain retreat. Only after weeks of training does she learn her assignment: she will be one of several young women tasting the Führer's food, offering herself in sacrifice to keep him from being poisoned.

Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.

Generations of Sassers have made moonshine in the Brushy Mountains of Wilkes County, North Carolina. Their history is recorded in a leather-bound journal that belongs to Jessie Sasser's daddy, but Jessie wants no part of it. As far as she's concerned, moonshine caused her mother's death a dozen years ago. Her father refuses to speak about her mama, or about the day she died. But Jessie has a gnawing hunger for the truth - one that compels her to seek comfort in food.

It's not just a thousand miles that separates Hanna Majewski from her younger sister, Stefa. There is another gulf—between the traditional Jewish ways that Hanna chose to leave behind in Warsaw, and her new, independent life in London. But as autumn of 1940 draws near, Germany begins a savage aerial bombing campaign in England, killing and displacing tens of thousands. Hanna, who narrowly escapes death, is recruited as a spy in an undercover operation that sends her back to her war-torn homeland.

It's 1945: When the critically wounded Captain Cooper Ravenal is brought to a private hospital on Manhattan's Upper East Side, young Dr. Kate Schuyler is drawn into a complex mystery that connects three generations of women in her family to a single extraordinary room in a Gilded Age mansion. Who is the woman in Captain Ravenel's portrait miniature who looks so much like Kate? And why is she wearing the ruby pendant handed down to Kate by her mother?

Missouri, February 1874: The last thing struggling homesteader Ginny needs is a scandal on her hands. But when a badly injured drifter arrives at Snow Farm in desperate need of medical attention, Ginny’s kind nature and good upbringing means she has no choice but to treat his wounds and care for him until he’s back on his feet, no matter the danger he might pose.

Ellis Island, 1902. Francesca arrives on the shores of America, her sights set on a better life than the one she left in Italy. That same day, aspiring linguist Alma reports to her first day of work at the immigrant processing center. Ellis, though, is not the refuge it first appears thanks to President Roosevelt's attempts to deter crime. Francesca and Alma will have to rely on each other to escape its corruption and claim the American dreams they were promised.

On the last day of eighth grade, Maggie begins to dream of finding a way to escape the drudgery and confinement of life in the hollow and establish her independence. Her plan begins to fall in place when she enters high school and discovers she has a natural talent for excelling in shorthand, typing, and other business classes. Meanwhile she spares no effort in helping her family continue to survive despite their poverty, a less than fertile few acres, and a family history of instability.