St Angelus runs like a family: the workers take care of their own - a lesson the mysterious new assistant matron, Miss Van Gilder, is about to learn the hard way. Little Joe has had trouble breathing but the doctors don’t take his sister Lily’s concerns seriously, least of all Miss Van Gilder. The nurses of Lovely Lane have a secret which is dividing their close knit group and when Nurse Pammy Tanner once again breaks the rules, her actions threaten them all.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

In postwar Tarabeg, two women are waiting for ambitious Michael Malone to return home. Rosie is the local schoolteacher, and most people think she is promised to him. Just a few have guessed that he has secretly begun to woo Sarah, whose brutal fisherman father would kill her if he knew. Both Rosie and Sarah love Michael, both hope to become his wife and their lives will interweave in a tale of tangled secrets, old promises and new feuds. Michael Malone's choice will have fateful consequences for everyone - especially, in due course, for his young daughter....

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

The three sisters of Victory Walk in East London will face heartache and tears on the home front. As rationing, blackouts and bombs start to bite, life will change forever for the three sisters.

Bristol 1936. Jenny Crawford has resigned herself to a loveless marriage living hand to mouth with their two children. Like many others, husband Roy struggles to find work at the docks but a chance encounter turns the family's fortunes around. Not only does he get regular work but they are also allocated a council house on Coronation Close on the outskirts of the city. Jenny and the children are overjoyed, this is the fresh start she could only ever dream of. But trouble feels never too far away.

Bristol 1939. At forty years of age, Mary Anne Randall still turns heads. With an abusive husband spending most of his wages on beer, she has resigned herself to be the sole breadwinner to protect her family and keep the wolves from the door. In order to make ends meet, Mary Anne runs a pawnbroking business from the wash house at the end of the garden. Following the outbreak of war an opportunity presents itself to escape her loveless marriage and find true love. Will she take that chance, or carry on living just for her children and not for herself?

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Sunderland, 1940, and the women go to the shipyards to do their bit for the war effort. Polly never dreamed she would be able to work in the shipyards like the men in her family but times are tough and her new job ends up giving her more than she ever expected when she meets enigmatic dock diver Tommy Watts. During the day, head welder Rosie teaches her fledgling flock of trainees their new trade, but at night she hides a secret life. And mother hen Gloria signs up to escape her brutal husband, but finds she cannot run....

Eudora Honeysett is done with this noisy, moronic world - all of it. She has witnessed the indignities and suffering of old age and has lived a full life. At 85, she isn’t going to leave things to chance. Her end will be on her terms. With one call to a clinic in Switzerland, a plan is set in motion. Then she meets 10-year-old Rose Trewidney, a whirling, pint-sized rainbow of sparkling cheer. All Eudora wants is to be left alone to set her affairs in order.

Cassandra Hale grew up knowing little about her parentage, and she had made peace with the fact that she never would. But her world shifts when a shocking deathbed confession reveals a two-year-old letter from Mr. Clark, the master of Briarton Park, with hints to her family's identity. Stung by betrayal, Cassandra travels to the village of Anston only to learn Mr. Clark has since passed away.

London, 1935. Ruby is always hungry, but she will go without if it means her young brothers can eat. 1930s Bermondsey might be called the larder of London, with its pie, pickle and jam factories, but for the poor working classes, starvation is often only a heartbeat away. When Ruby's neighbour suggests she ought to go to the Methodist Mission for free food, Ruby knows her father will be furious, but she has no other option.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

In weekly phone calls to his daughter in Australia, widower Hubert Birdpaints a picture of the perfect retirement, packed with fun, friendship, and fulfillment. But it's a lie. In reality, Hubert's days are all the same, dragging on without him seeing a single soul. Until he receives some good news - good news that in one way turns out to be the worst news ever, news that will force him out again, into a world he has long since turned his back on.