After years of trying to become pregnant without success, Rachel Dawson and her husband Thomas felt their dreams had finally come true the day they brought home their newly adopted twin babies. Though the lawyer Baron Bell who arranged for the surrogate mother charged a hefty six-figure fee, one glance into the eyes of their precious children told them it was all worth it - until the birth mother reappeared, first demanding more money, then the twins themselves.

On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

Olivia Lowell always believed her father's claim that her mother died in childbirth, until the shocking day a lawyer informs her that her mother has just passed away, leaving her a fortune. The money comes with a caveat - and a confession. In her will, Olivia's mother reveals that she and two college friends committed a crime long ago, and now she wants Olivia to track down her accomplices and convince them to come clean.

For generations, the Windsors have lived on the family's grand estate in Crestwood, South Carolina, as intertwined with local life as sweet tea and pecan pie. Now, on the anniversary of her daughter Emily's death, Sarabess Windsor believes she may be the last to carry the family name - unless she can find her second daughter, Trinity, who disappeared 15 years ago.

When Samantha Rainford - newly wed to Douglas Cosmo Rainford III - returns home from her honeymoon to find divorce papers waiting, she's shocked and heartbroken. Then she discovers that she's not the first to be abandoned - she's one of four (or maybe more) ex-Mrs. Rainfords - and decides it's time to put into practice that old truism: Don't get mad, get even.

College senior Lily Madison is on her own and desperate to pay for her last semester of school. With nowhere to turn, she makes the difficult decision to donate her eggs to a fertility clinic. Sam Parker is also a penniless student who supplements his tuition money by visiting a sperm bank. One day, Lily and Sam meet at the clinic and talk about their secret. Despite their obvious attraction, Lily and Sam go their separate ways.

Raised on her father's South Carolina plantation, Callie Parker wanted for nothing, and now she is about to marry wealthy local scion Wyn Archer. But her wedding wouldn't be complete without the three people she grew up with under the sheltering branches of the angel oaks at Parker Manor.

Darby Lane and Russell Gunn had been inseparable friends since their days in the Horseshoe, the wonderful Baton Rouge neighborhood of their youth. But after graduate school, a tragic accident takes Russ’s life - and Darby’s world is shattered. Her long journey to healing brings her closer to Russ’s brother Ben, whom she begins to see through new eyes. Suddenly love blooms in the place of grief; and now, with the help of the three wily and colorful aunts who raised her, Darby faces the challenge of reuniting Ben with his estranged father....

If her abusive husband hadn't tried to kill her and her beloved dog Lucie, Helen Ward might never have left her million-dollar home and run far away. Now Helen's changed her identity and moved across the country, hopeful that she can be safe, happy, maybe even loved. And when she meets college professor Sam Tolliver, she begins to believe fairytales do come true.

Professional mountaineer Lily is building a new life for herself - in ways she never would have expected. She's traded the mountain wilderness of Wyoming for the lush river country of the deep South, where she is busy restoring a fine old Natchez, Mississippi house. And she's rediscovered happiness with Matt Starr, the man she has always loved. But Lily's dreams for the future are suddenly threatened when Matt disappears without a trace.

An only child who lost both parents during her first year at college, wealthy heiress Kristine Kelly had made her husband her whole world. But she didn't see what everyone else did: that handsome, charismatic Logan Kelly was a manipulator and a user. Then, one cold December, Kristine got a chilling wake-up call when Logan vanished, along with the eight-million-dollar trust fund she had naively given him the power to control.

Satisfied with her life and a new relationship, Abby Mitchell is most happy to be reunited with her sister, who was separated from her after their parents died. The siblings are planning a sumptuous party, unaware that an uninvited guest is coming, one who'll do anything to help keep the past hidden.