
Doctored
Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's
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Narrated by:
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Lyle Blaker
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By:
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Charles Piller
About this listen
“Demonstrates how some of the most accomplished and elite scientific gatekeepers may have lied, cheated, squandered trust and endangered lives.”—The Wall Street Journal
For fans of Empire of Pain and Dopesick, an arresting deep dive into how Alzheimer’s disease treatment has been set back by corrupt researchers, negligent regulators, and the profit motives of Big Pharma.
Nearly seven million Americans live with Alzheimer’s disease, a tragedy that is already projected to grow into a $1 trillion crisis by 2050. While families suffer and promises of pharmaceutical breakthroughs keep coming up short, investigative journalist Charles Piller’s Doctored shows that we’ve quite likely been walking the wrong path to finding a cure all along—led astray by a cabal of self-interested researchers, government accomplices, and corporate greed.
Piller begins with a whistleblower—Vanderbilt professor Matthew Schrag—whose work exposed a massive scandal. Schrag found that a University of Minnesota lab led by a precocious young scientist and a Nobel Prize-rumored director delivered apparently falsified data at the heart of the leading hypothesis about the disease. Piller’s revelations of Schrag’s findings stunned the field and the public.
From there, based on years of investigative reporting, this “seminal account of deceit that will long be remembered” (Katherine Eban, author of Bottle of Lies and Vanity Fair special correspondent) exposes a vast network of deceit and its players, all the way up to the FDA. Piller uncovers evidence that hundreds of important Alzheimer’s research papers are based on false data. In the process, he reveals how even against a flood of money and influence, a determined cadre of scientific renegades have fought back to challenge the field’s institutional powers in service to science and the tens of thousands of patients who have been drawn into trials to test dubious drugs. It is a shocking tale with huge ramifications not only for Alzheimer’s disease, but for scientific research, funding, and oversight at large.
©2025 Charles Piller (P)2025 Simon & Schuster AudioListeners also enjoyed...
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Aubrey Clayton traces the history of how statistics went astray, beginning with the groundbreaking work of the 17th-century mathematician Jacob Bernoulli and winding through gambling, astronomy, and genetics. Clayton recounts the feuds among rival schools of statistics, exploring the surprisingly human problems that gave rise to the discipline and the all-too-human shortcomings that derailed it.
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Rigorously Bayesian
- By Anonymous User on 01-25-22
By: Aubrey Clayton
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Letters from an Astrophysicist
- By: Neil deGrasse Tyson
- Narrated by: Neil deGrasse Tyson, Vikas Adam, Piper Goodeve, and others
- Length: 5 hrs and 35 mins
- Unabridged
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Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.
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Dear Neil...
- By Tina G. on 10-14-19
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Inspired
- How to Create Tech Products Customers Love, Second Edition
- By: Marty Cagan
- Narrated by: Marty Cagan
- Length: 7 hrs and 45 mins
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How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.
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Great book, terrible audio wanted to ask a refund
- By Srikanth Ramanujam on 11-15-18
By: Marty Cagan
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Ranger Confidential
- Living, Working, and Dying in the National Parks
- By: Andrea Lankford
- Narrated by: Julia Motyka
- Length: 9 hrs and 28 mins
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The real stories behind the scenery of America’s national parks. For 12 years, Andrea Lankford lived in the biggest, most impressive national parks in the world, working a job she loved. She chaperoned baby sea turtles on their journey to sea. She pursued bad guys on her galloping patrol horse. She jumped into rescue helicopters bound for the heart of the Grand Canyon. She won arguments with bears. She slept with a few too many rattlesnakes. Hell yeah, it was the best job in the world! Fortunately, Andrea survived it.
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Depressing from Cover to Cover
- By Drew (@drewsant) on 04-13-15
By: Andrea Lankford
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The Quantum Universe
- (And Why Anything That Can Happen, Does)
- By: Brian Cox, Jeff Forshaw
- Narrated by: Samuel West
- Length: 8 hrs and 28 mins
- Unabridged
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In The Quantum Universe, Brian Cox and Jeff Forshaw approach the world of quantum mechanics in the same way they did in Why Does E=mc2? and make fundamental scientific principles accessible - and fascinating - to everyone.The subatomic realm has a reputation for weirdness, spawning any number of profound misunderstandings, journeys into Eastern mysticism, and woolly pronouncements on the interconnectedness of all things. Cox and Forshaw's contention? There is no need for quantum mechanics to be viewed this way.
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Not suitable as an audio book
- By SPN on 03-29-22
By: Brian Cox, and others
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Welcome to the Universe
- An Astrophysical Tour
- By: Michael A. Strauss, J. Richard Gott, Neil deGrasse Tyson
- Narrated by: Michael Butler Murray
- Length: 17 hrs and 53 mins
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Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.
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All About What We Know About the Universe - ALL
- By J.B. on 02-17-17
By: Michael A. Strauss, and others
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Have you ever imagined being caught in an unexpected emergency or stranded in the wilderness with no one to rely on but yourself? What if you had the knowledge and skills to not just survive but thrive in any situation? Survival Skills for Beginners is your definitive guide to navigating life’s most challenging moments. Packed with actionable insights, proven techniques, and practical advice, this comprehensive survival handbook will empower you to face the wild, prepare for emergencies, and build resilience for any crisis. What You’ll Learn in This Book Survival Fundamentals: ...
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The conclusions of the author are pretty much what you would expect.
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Is sex with The Hulk technically a threesome? Does The Flash do everything faster? Has Wonder Woman really never faked an orgasm? Explore these questions and more with this collection of speculative, comedic essays on how superpowers might affect the sex lives of famous superheroes. Based on genuine scientific research and both Marvel and DC comic book and movie canon (and more!), Sex Lives of Superheroes is a refreshingly frank and fun deep dive into the pros, cons, and plot twists of superpowered sex.
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Research
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What listeners say about Doctored
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- Amazon Customer
- 03-08-25
Misconduct is the antithesis of science
I’m writing this 5star review because the only review is an idiotic 1star that to me doesn’t seem like it’s from someone who read the book. This isn’t a book about cutting edge Alzheimer’s research, it doesn’t give you a “view” on what the facts are behind Alzheimer’s, it just calls out rampant and horrifying misconduct. So maybe the amyloid hypothesis is perfectly correct, but the bulk of the science it’s currently built off is falsified and corrupt and worse than worthless, it’s active dishonesty via data manipulation and more which isn’t just bad science, it the antithesis of science. So the book really isn’t offering a perspective on the causes of Alzheimer’s etc. it’s just calling out the abominable conduct of a shocking number of big names in the field. Anyone acting like manipulating the data you draw conclusions from isn’t a big deal is not only not a scientist, they are an idiot. Sorry 1 star reviewer, I think you are maybe a bit dumb.
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- Alz Sci
- 02-16-25
A one-sided view of the Alzheimer’s field
As an Alzheimer’s researcher I found this very biased and dismissive of the great strides that have been made in our field. Misconduct must always be called out and addressed fully, and for that Mr Piller is to be credited. But beyond that, the book tells a semi-fictional story of our research field.
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