A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

In The Optimist, the Wall Street Journal reporter Keach Hagey presents the most detailed account yet of Altman’s rise, from his precocious childhood in St. Louis to his first, failed startup experience; his time as legendary entrepreneur Paul Graham’s protégé and successor as head of Y Combinator, the start-up accelerator where Altman became the premier power broker in Silicon Valley; the founding of OpenAI and his recruitment of a small yet superior team; and his struggle to keep his company at the cutting edge while fending off determined rivals, including Elon Musk.

Within the next five years, Jeremy Kahn predicts, AI will disrupt almost every industry and enterprise, with vastly increased efficiency and productivity. It will restructure the workforce, making AI copilots a must for every knowledge worker. It will compel us to reimagine how we make art, compose music, and write and publish books. The potential of generative AI to extend our skills, talents, and creativity as humans is undeniably exciting and promising. But while this new technology has a bright future, it also casts a dark and fearful shadow.

Daughter. Duhitár-. Dustr. Dukte. Listen to these English, Sanskrit, Armenian and Lithuanian words, all meaning the same thing, and you hear echoes of one of history’s most unlikely journeys. All four languages—along with hundreds of others, from French and Gaelic, to Persian and Polish—trace their origins to an ancient tongue spoken as the last ice age receded. This language, which we call Proto-Indo-European, was born between Europe and Asia and exploded out of its cradle, fragmenting as it spread east and west.

Drawing in part on his own experiences, including with policymakers and world leaders, Kenneth Rogoff animates the remarkable postwar run of the dollar—how it beat out the Japanese yen, the Soviet ruble, and the euro—and the challenges it faces today from crypto and the Chinese yuan, the end of reliably low inflation and interest rates, political instability, and the fracturing of the dollar bloc.

Confused about AI and worried about what it means for your future and the future of the world? You’re not alone. AI is everywhere—and few things are surrounded by so much hype, misinformation, and misunderstanding. In AI Snake Oil, computer scientists Arvind Narayanan and Sayash Kapoor cut through the confusion to give you an essential understanding of how AI works, why it often doesn’t, where it might be useful or harmful, and when you should suspect that companies are using AI hype to sell AI snake oil—products that don’t work, and probably never will.

What is life? In this penetrating and wide-ranging book, world-renowned physicist and science communicator Paul Davies searches for answers in a field so new and fast-moving that it lacks a name; it is a domain where biology, computing, logic, chemistry, quantum physics, and nanotechnology intersect.

Renowned statistician David Spiegelhalter shows how we can become better at dealing with what we don't know to make smarter choices in a world so full of puzzling variables. In lucid, lively prose, Spiegelhalter guides us through the principles of probability, illustrating how they can help us think more analytically about everything from medical advice to sports to climate change forecasts.

Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving.

Whether we like it or not, the AI revolution is coming to education. In Brave New Words, Salman Khan, the visionary behind Khan Academy, explores how artificial intelligence and GPT technology will transform learning, and offers a road map for teachers, parents, and students to navigate this exciting (and sometimes intimidating) new world. A pioneer in the field of education technology, Khan examines the ins and outs of these cutting-edge tools and how they will revolutionize the way we learn and teach.

Vince Beiser explores the Achilles’ heel of “green power” and digital technology–that manufacturing computers, cell phones, electric cars, and other technologies demand skyrocketing amounts of lithium, copper, cobalt, and other materials. Around the world, businesses and governments are scrambling for new places and new ways to get those metals, at enormous cost to people and the planet. Beiser crisscrossed the world to talk to the people involved and report on the damage this race is inflicting, the ways it could get worse, and how we can minimize the damage.

Shannon Vallor makes a wide-ranging, prophetic, and philosophical case for what AI could be: a way to reclaim our human potential for moral and intellectual growth, rather than lose ourselves in mirrors of the past. Rejecting prophecies of doom, she encourages us to pursue technology that helps us recover our sense of the possible, and with it the confidence and courage to repair a broken world. Vallor calls us to rethink what AI is and can be, and what we want to be with it.

There is a robotics revolution underway. A record 3.1 million robots are working in factories right now, doing everything from assembling computers to packing goods and monitoring air quality and performance. A far greater number of smart machines impact our lives in countless other ways—improving the precision of surgeons, cleaning our homes, extending our reach to distant worlds—and we’re on the cusp of even more exciting opportunities.

At its simplest, Bayes’s theorem describes the probability of an event, based on prior knowledge of conditions that might be related to the event. But in Everything Is Predictable, Tom Chivers lays out how it affects every aspect of our lives. He explains why highly accurate screening tests can lead to false positives and how a failure to account for it in court has put innocent people in jail. A cornerstone of rational thought, many argue that Bayes’s theorem is a description of almost everything. But who was the man who lent his name to this theorem?

We are entering a new technological age in which artificial intelligence and immersive media will transform society at all levels, mediating our lives by altering what we see, hear, and experience. If managed well, this could unleash a new age of abundance. If managed poorly, this technological revolution could easily go astray, compromising our privacy, autonomy, agency, and humanity. Two industry veterans provide a data-driven debate on whether the new world we're creating will be a technological utopia or an AI-powered dystopia and give guidance on how to aim for the best future we can.

From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic engineering is shaking the core foundations of our lives-sex, war, love, and death. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.

A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer.

Sacred Knowledge is the first well-documented, sophisticated account of the effect of psychedelics on biological processes, human consciousness, and revelatory religious experiences. Based on nearly three decades of legal research with volunteers, William A. Richards argues that, if used responsibly and legally, psychedelics have the potential to assuage suffering and constructively affect the quality of human life.

Blue Magic, the latest designer drug linked to a rash of overdoses, might explain the needle mark on the arm of a young woman found dead in her Kansas City apartment. But when star reporter Rich Azadian digs deeper, the clues point to a far more explosive story: MaryLee Stock was a special protege of evangelical megapastor and power broker Cobalt Becker, who is poised to deliver his followers and the presidency to a firebrand right-wing senator in the next election.

In this searing exposé, former Wall Street insider Nomi Prins shows how the 2007-2008 financial crisis turbo-boosted the influence of central bankers and triggered a massive shift in the world order. Packed with tantalizing details about the elite players orchestrating the world economy, Collusion takes the listener inside the most discreet conversations at exclusive retreats like Jackson Hole and Davos. A work of meticulous reporting and bracing analysis, Collusion will change the way we understand the new world of international finance.

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.

No other monument in the world evokes mystery like the Great Sphinx of Giza. It has survived the harsh climate of Egypt for thousands of years and will remain long after our own civilization is gone. According to orthodox Egyptology, the Sphinx was built around 2500 BCE as a memorial to the pharaoh Khafre. Yet this “fact” has scant to no supportive evidence. When was the Sphinx really built and, most importantly, why?

Within the next five years, Jeremy Kahn predicts, AI will disrupt almost every industry and enterprise, with vastly increased efficiency and productivity. It will restructure the workforce, making AI copilots a must for every knowledge worker. It will compel us to reimagine how we make art, compose music, and write and publish books. The potential of generative AI to extend our skills, talents, and creativity as humans is undeniably exciting and promising. But while this new technology has a bright future, it also casts a dark and fearful shadow.

The lessons taught by ancient Chinese philosophers surprisingly still apply, and they challenge our fundamental assumptions about how to lead a fulfilled, happy, and successful life. Self-discovery, it turns out, comes through looking outward, not inward. Power comes from holding back. Good relationships come from small gestures. Spontaneity comes from practice. And excellence comes from what you choose to do, not your "natural" abilities.

When John O'Leary was nine years old, he was almost killed in a devastating house fire. With burns on 100 percent of his body, O'Leary mustered an almost unimaginable amount of inner strength just to survive the ordeal. The insights he gained through this experience and the heroes who stepped into his life to help him through the journey - his family, the medical staff, and total strangers - changed his life. Now he is committed to living life to the fullest and inspiring others to do the same.

A squirrel in the garden. A rat in the wall. A pigeon on the street. Humans have spent so much of our history drawing a hard line between human spaces and wild places. When animals pop up where we don’t expect or want them, we respond with fear, rage, or simple annoyance. It’s no longer an animal. It’s a pest. At the intersection of science, history, and narrative journalism, Pests is not a simple call to look closer at our urban ecosystem. It’s not a natural history of the animals we hate. Instead, this book is about us.

Studying zoology made Lucy Cooke feel like a sad freak. Not because she loved spiders or would root around in animal feces: All her friends shared the same curious kinks. The problem was her sex. Being female meant she was, by nature, a loser. Since Charles Darwin, evolutionary biologists have been convinced that the males of the animal kingdom are the interesting ones—dominating and promiscuous, while females are dull, passive, and devoted. But Cooke tells a new story.

Blending history, science, and culture, a stunning and highly engaging evolutionary story exploring how walking on two legs allowed humans to become the planet’s dominant species.