A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: Nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?

What is life? In this penetrating and wide-ranging book, world-renowned physicist and science communicator Paul Davies searches for answers in a field so new and fast-moving that it lacks a name; it is a domain where biology, computing, logic, chemistry, quantum physics, and nanotechnology intersect.

The Blind Spot goes where no science book goes, urging us to create a new scientific culture that views ourselves both as an expression of nature and as a source of nature's self-understanding, so that humanity can flourish in the new millennium.

Among the estimated 100 billion solar systems in the known universe, evolving life is surely abundant. That evolution is a process of "becoming" in each case. Since Newton, we have turned to physics to assess reality. But physics alone cannot tell us where we came from, how we arrived, and why our world has evolved past the point of unicellular organisms to an extremely complex biosphere.

What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.

While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer.

If the history of the Earth were compressed down to a year, our species would arise in the last thirty minutes or so of the final hour. But life itself is not such a late arrival: It has existed on Earth for something like 3.7 billion years—most of our planet’s history and over a quarter of the age of the universe (as far as we can tell). What have these organisms—bacteria, animals, plants, and the rest—done in all this time? In Living on Earth, the philosopher Peter Godfrey-Smith proposes a new way of understanding how the actions of living beings have shaped our planet.

Decades of research document plants' impressive abilities: they communicate with one another, manipulate other species, and move in sophisticated ways. Lesser known, however, is the new evidence that plants may actually be sentient. Although plants may not have brains, their microscopic commerce exposes a system not unlike the neuronal networks running through our own bodies. Paco Calvo offers an entirely new perspective on plant biology. In Planta Sapiens, he shows for the first time how we can use tools developed in animal cognition studies in a quest to deeply understand plant intelligence.

The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.

Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.

In a rarified world of scientific research, a revolution has been brewing. Its activists are not anarchists, but rather Nobel Laureates in physics and economics and pony-tailed graduates, mathematicians, and computer scientists from all over the world. They have formed an iconoclastic think-tank and their radical idea is to create a new science: complexity. They want to know how a primordial soup of simple molecules managed to turn itself into the first living cell--and what the origin of life some four billion years ago can tell us about the process of technological innovation today.

One of humanity’s oldest beliefs is that our world is alive. Though once ridiculed by some scientists, the idea of Earth as a vast interconnected living system has gained acceptance in recent decades. We, and all living things, are more than inhabitants of Earth—we are Earth, an outgrowth of its structure and an engine of its evolution. Life and its environment have coevolved for billions of years, transforming a lump of orbiting rock into a cosmic oasis—a planet that breathes, metabolizes, and regulates its climate.

How do neurons turn into minds? The problem of consciousness has gnawed at us for millennia. In the last century there have been massive breakthroughs that have rewritten the science of the brain, and yet the puzzles faced by the ancient Greeks are still present. In The Consciousness Instinct, the neuroscience pioneer Michael S. Gazzaniga puts the latest research in conversation with the history of human thinking about the mind, giving a big-picture view of what science has revealed about consciousness.

Over billions of years, ancient fish evolved to walk on land, reptiles transformed into birds that fly, and apelike primates evolved into humans that walk on two legs, talk, and write. For more than a century, paleontologists have traveled the globe to find fossils that show how such changes have happened.

We are in the midst of a global mental health crisis, and mental illnesses are on the rise. But what causes mental illness? And why are mental health problems so hard to treat? Drawing on decades of research, Harvard psychiatrist Dr. Chris Palmer outlines a revolutionary new understanding that for the first time unites our existing knowledge about mental illness within a single framework: mental disorders are metabolic disorders of the brain. Brain Energy will transform the field of mental health, and the lives of countless people around the world.

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.

How the Earth Works takes you on an astonishing journey through time and space. In 48 lectures, you will look at what went into making our planet - from the big bang, to the formation of the solar system, to the subsequent evolution of Earth.

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

My Big TOE: Awakening, written by a nuclear physicist in the language of contemporary culture, unifies science and philosophy, physics and metaphysics, mind and matter, purpose and meaning, the normal and the paranormal. The entirety of human experience (mind, body, and spirit) including both our objective and subjective worlds is brought together under one seamless scientific understanding.

Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.

At the end of his career, Albert Einstein was pursuing a dream far more ambitious than the theory of relativity. He was trying to find an equation that explained all physical reality - a theory of everything. Experimental physicist and award-winning educator Dr. Don Lincoln takes you on this exciting journey in The Theory of Everything: The Quest to Explain All Reality. Suitable for the intellectually curious at all levels and assuming no background beyond basic high-school math, these 24 half-hour lectures cover recent developments at the forefront of particle physics and cosmology.

In Your Brain Is a Time Machine, brain researcher and best-selling author Dean Buonomano draws on evolutionary biology, physics, and philosophy to present his influential theory of how we tell and perceive time. The human brain, he argues, is a complex system that not only tells time but creates it; it constructs our sense of chronological flow and enables "mental time travel" - simulations of future and past events.

How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.

At every moment, within our bodies and all around us, trillions of microscopic combatants are waging a war that shapes our health and life on Earth. Countless times per second, viruses known as phages attack and destroy bacteria while leaving all other life forms, including us, unscathed. Vastly outnumbering the viruses that do us harm, phages power ecosystems, drive evolutionary innovation, and harbor a remarkable capacity to heal life-threatening infections when conventional antibiotics fail. Yet most of us have never heard of them, thinking of viruses only as enemies to be feared.

It is rare for life to change Earth, yet three organisms have profoundly transformed our planet over the long course of its history. Elemental reveals how microbes, plants, and people used the fundamental building blocks of life to alter the climate, and with it, the trajectory of life on Earth in the past, present, and future. Taking listeners from the deep geologic past to our current era of human dominance, Stephen Porder focuses on five of life’s essential elements—hydrogen, oxygen, carbon, nitrogen, and phosphorus.

Named one of the top books of 2009 by the Times Literary Supplement (London), this controversial and compelling audiobook from Dr. Stephen C. Meyer presents a convincing new case for intelligent design (ID) based on revolutionary discoveries in science and DNA. Along the way Meyer argues that Charles Darwin's theory of evolution as expounded in The Origin of Species did not, in fact, refute ID.

A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

Each of us began life as a single cell. From this humble origin, we embarked on a risky journey fraught with opportunities for disaster. Yet, amazingly, we reached our destination intact, emerging as dazzlingly complex, exquisitely engineered assemblages of trillions of cells. This metamorphosis constitutes one of nature's most spectacular yet commonplace magic tricks—and one of its most coveted secrets. In From One Cell, physician and researcher Ben Stanger offers a glimpse into what scientists are discovering about how life and the body take shape.

Charles Darwin’s theories, first published more than 150 years ago, still set the paradigm of how we understand the evolution of life—but scientific advances of recent decades have radically altered that understanding. In fact the currently accepted history of life on Earth is flawed and out of date. Now two pioneering scientists, one already an award-winning popular author, deliver an eye-opening narrative that synthesizes a generation’s worth of insights from new research.

History is the most dangerous place on earth. From dinosaurs the size of locomotives to meteors big enough to sterilize the planet, from famines to pandemics, from tornadoes to the Chicxulub asteroid, the odds of human survival are slim but not zero—at least, not if you know where to go and what to do. In each chapter of How to Survive History, Cody Cassidy explores how to survive one of history’s greatest threats: getting eaten by dinosaurs, being destroyed by the asteroid that wiped out the dinosaurs, succumbing to the lava flows of Pompeii, being devoured by the Donner Party, and more.

While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer.

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.