Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds.

Widowed in Memphis during 1932, Cecile Dowd is struggling to provide for her three-year-old daughter. Unwittingly trusting a neighbor puts little Millie Mae into the clutches of Georgia Tann, corrupt Memphis Tennessee Children's Home Society director suspected of the disappearance of hundreds of children. With the help of a sympathetic lawyer, the search for Millie uncovers a deep level of corruption that threatens their very lives.

When concert pianist Vivienne Mourdant’s father dies, he leaves to her the care of a patient at Hurstwell Asylum. Vivienne had no idea the woman existed, and yet her portrait is shockingly familiar. When the asylum claims she was never a patient there, Vivienne is compelled to discover what happened to the figure she remembers from childhood dreams.

On May 1, 1915, with WWI entering its tenth month, a luxury ocean liner as richly appointed as an English country house sailed out of New York, bound for Liverpool, carrying a record number of children and infants. The passengers were surprisingly at ease, even though Germany had declared the seas around Britain to be a war zone. For months, German U-boats had brought terror to the North Atlantic.

At once an incredible adventure narrative and a penetrating biographical portrait, The River of Doubt is the true story of Theodore Roosevelt's harrowing exploration of one of the most dangerous rivers on earth.