
Transformer
The Deep Chemistry of Life and Death
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Narrated by:
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Richard Trinder
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By:
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Nick Lane
About this listen
For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.
Lane is among the vanguard of researchers asking why the Krebs cycle, the "perfect circle" at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane's voyage, as a biochemist, to find the inner meaning of the Krebs cycle-why it is still spinning at the heart of life and death today.
Transformer unites the story of our planet with the story of our cells-what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane's talent for distilling and humanizing complex research, Transformer is a must-listen for anyone fascinated by biology's great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
©2022 Nick Lane (P)2022 TantorListeners also enjoyed...
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Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: Nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?
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More woo than new
- By Gary on 09-09-15
By: Johnjoe McFadden, and others
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Liquid Rules
- The Delightful and Dangerous Substances That Flow Through Our Lives
- By: Mark Miodownik
- Narrated by: Michael Page
- Length: 7 hrs and 16 mins
- Unabridged
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We all know that without water we couldn't survive, and that sometimes a cup of coffee or a glass of wine feels just as vital. But do we really understand how much we rely on liquids, or the destructive power they hold? Set over the course of a flight from London to San Francisco, Liquid Rules offers listeners a fascinating tour of these formless substances, told through the language of molecules, droplets, heartbeats, and ocean waves.
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Interesting book!
- By Wayne on 08-04-19
By: Mark Miodownik
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Significant Figures
- The Lives and Work of Great Mathematicians
- By: Ian Stewart
- Narrated by: Roger Clark
- Length: 11 hrs and 39 mins
- Unabridged
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In Significant Figures, acclaimed mathematician Ian Stewart introduces the visionaries of mathematics throughout history. Delving into the lives of twenty-five great mathematicians, Stewart examines the roles they played in creating, inventing, and discovering the mathematics we use today. Through these short biographies, we get acquainted with the history of mathematics.
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Beware
- By Anton Kurtz on 12-08-18
By: Ian Stewart
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A User's Guide to the Brain
- Perception, Attention, and the Four Theaters of the Brain
- By: John J. Ratey
- Narrated by: Eric Martin
- Length: 16 hrs and 38 mins
- Unabridged
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John Ratey, best-selling author and clinical professor of psychiatry at Harvard Medical School, lucidly explains the human brain's workings, and paves the way for a better understanding of how the brain affects who we are. Ratey provides insight into the basic structure and chemistry of the brain, and demonstrates how its systems shape our perceptions, emotions, and behavior. By giving us a greater understanding of how the brain responds to the guidance of its user, he provides us with knowledge that can enable us to improve our lives.
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Great book, mediocre narration
- By Dr. B on 09-25-18
By: John J. Ratey
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Paradox
- The Nine Greatest Enigmas in Physics
- By: Jim Al-Khalili
- Narrated by: Matthew Waterson
- Length: 6 hrs and 54 mins
- Unabridged
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Throughout history, scientists have come up with theories and ideas that just don't seem to make sense. These we call paradoxes. The paradoxes Al-Khalili offers are drawn chiefly from physics and astronomy and represent those that have stumped some of the finest minds. With elegant explanations that bring the listener inside the mind of those who've developed them, Al-Khalili helps us to see that, in fact, paradoxes can be solved if seen from the right angle.
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Almost Useless
- By Michael on 06-19-19
By: Jim Al-Khalili
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- By: Nathan H. Lents
- Narrated by: L.J. Ganser
- Length: 7 hrs and 54 mins
- Unabridged
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We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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From Pointless Bones to Broken Genes to...Aliens?
- By Katy.LED on 12-04-18
By: Nathan H. Lents
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Energy and Civilization
- A History
- By: Vaclav Smil
- Narrated by: David Colacci
- Length: 20 hrs and 9 mins
- Unabridged
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In this monumental history, Vaclav Smil provides a comprehensive account of how energy has shaped society, from pre-agricultural foraging societies through today's fossil fuel-driven civilization and offers listeners a magisterial overview of humanity's energy eras.
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Not a good format for this book
- By C. Hoogeboom on 05-19-18
By: Vaclav Smil
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Journey to the Edge of Reason
- The Life of Kurt Gödel
- By: Stephen Budiansky
- Narrated by: Bob Souer
- Length: 8 hrs and 52 mins
- Unabridged
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Nearly a hundred years after its publication, Kurt Gödel's famous proof that every mathematical system must contain propositions that are true - yet never provable - continues to unsettle mathematics, philosophy, and computer science. Yet unlike Einstein, with whom he formed a warm and abiding friendship, Gödel has long escaped all but the most casual scrutiny of his life.
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Interesting story of a great mathematician
- By James Orlin on 04-28-22
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The Song of the Cell
- An Exploration of Medicine and the New Human
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 16 hrs and 3 mins
- Unabridged
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From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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Beyond Words Wonderful
- By Lynn on 11-27-22
What listeners say about Transformer
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- Gabriel Weiss
- 01-25-23
Excellent Exploration of the Krebs Cycle
If you love biochemistry and its relevance to understanding life and our place on this planet or even if you simply wish to contemplate how the dance of molecules might generate consciousness, then this is a must read!
The epilogue hints at what I hope will be the direction of Lane’s future writings. I recommend reading it before the rest of the book and then again at the end.
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- roger olsson
- 07-19-23
Great and interesting book, I learnt a lot
I really enjoyed this book; the reading was slow in the first two chapters (increasing the speed with 10% worked) but catched on after that.
I'm a little disappointed that the cool FAD small molecule is not mentioned in the electron transfers, FAD is really the electron donor in most cases not NADPH, the latter donates a hydride, while the FAD takes the hydride and split it into electrons and a proton.
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- Nate
- 07-11-23
A great story of life
I’m a computer scientist, physicist, and performing artist, and I found this book engaging and fascinating.
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- Yael
- 11-14-22
Don’t miss out this essential book!
This is his s best book thus far! Despite my prior knowledge in the field and some disagreements with some of the author’s conclusions, this is a book that every scientist must read (or science buff). The author was able to explain each puzzle piece in order that when he connects it all to a larger picture, the reader will be in awe. Whether the day to day of a scientist that comes to a great discovery without recognition from his surroundings (can inspire and give hope in the darkest of times) or how the current knowledge especially in mitochondria is the essential key to explain many biological processes. A must have and read! (Thank you for this book)
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2 people found this helpful
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- Paul Hillery
- 12-07-22
Great Book for Geneticists and Microbiologists
This book was a little over my head, although the author's style and the narrator's voice drew me in to try the clouds eye view, and therefore I did get some grasp of the deep science of microbiology and genetics. AND a dislike of phages!
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- Anonymous User
- 12-28-23
Great synthesis of important aspects of biochemistry.
It was a little tough for me in audio book format so I bought the book to allow me to review in more detail. Love the topic and the writing style.
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- sam
- 09-27-22
Like his other books, superb
If you like biochemistry and metabolism, this is the book for you. Once you go deep in Krebs cycle you can not unsee it. Highly recommend book
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13 people found this helpful
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- robert
- 02-25-23
Are used immersive learning for this book it was excellent
This book taught me a lot. Are used immersive learning subscribing to the Audible and Kindle version. Although I studied bio chemistry years ago, I found that my ability to memorize exceeded my understanding. Nick Lane explains the concepts sometimes with speculation. But now I have much more understanding and appreciation for bio chemistry, and it’s wonders.
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- Dan
- 09-23-22
Great Book - Bad Reading
Nick Lane’s work is fascinating and insightful, but the reader’s performance makes listening to the book difficult. Instead of reading naturally, he halts on every other word. These interruptions make the audible version of the book unlistenable for me. It’s possible this reading style works well for others, but be forewarned that listening may not be a comfortable experience.
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30 people found this helpful
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- Frank Gaertner
- 11-28-22
Best review of biochem explains origin of carbon based life
How life started, the roles of protons, water, proto-cells, vents, anaerobic life, oxygen, Krebs Cycle, Pentose Phosphate, acetyl-CoA, NADH, NADPH, flux, membranes, ATPases, cascades, electromotive force, steady states, non-equilibrium thermodynamics, potential energy, kinetic energy, molecular machines, mitochondria, aging, etc etc are all brought together in incredible coherency and clarity
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