In this episode of Daily Value, we look at science of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR), two NAD+ precursors gaining traction in longevity research. Both supplements aim to restore NAD+ levels, critical for energy metabolism and cellular repair, yet their distinct pathways and tissue-specific effects suggest considerations for choosing one over the other.

Discussion Points:

-The metabolic pathways of NMN and NR, highlighting how their mechanisms of action influence NAD+ synthesis across tissues.

-Insights from a 2024 study (in rodents - PMID: 38645109) demonstrating the dual effects of NMN: improvements in cardiac and liver function, alongside kidney inflammation linked to toxic metabolite accumulation at high doses.

-Clinical dosing strategies, safety considerations, and how age and tissue-specific needs may guide the choice between NMN and NR.

https://pubmed.ncbi.nlm.nih.gov/38645109/

https://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.511

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In this episode of Daily Value, we delve into the emerging evidence surrounding Urolithin A, a metabolite derived from gut bacteria that is showing potential for enhancing athletic performance and recovery in young healthy populations. Originating from dietary ellagitannins found in foods such as pomegranates, berries, and nuts, but also available as a supplement, Urolithin A’s ability to optimize mitochondrial function suggests new approaches to sports nutrition and physical performance.

Discussion Points:

-The mechanisms of Urolithin A, including its role in activating mitophagy to improve mitochondrial efficiency.

-Insights from recent clinical trials using supplemental Urolithin A, demonstrates its impact on strength, endurance, and markers of recovery, including inflammation and protein breakdown.

-The broader implications of Urolithin A for resistance-trained individuals and populations at risk of muscle decline.

https://pubmed.ncbi.nlm.nih.gov/39487653/

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This episode explores the critical connections between Vitamin D, muscle health, and energy metabolism, emphasizing its role in muscle protein synthesis, hypertrophy, and body composition. We discuss the latest research, clinical findings, and the importance of maintaining adequate Vitamin D levels for optimal skeletal muscle function.

• Understanding Vitamin D's unique secosteroid structure
• Role of Vitamin D in muscle function and regeneration
• Impact of Vitamin D deficiency on muscle strength across all ages
• Energy allocation: Vitamin D's role in shifting calories to muscles
• Myostatin inhibition and its influence on muscle growth
• Leptin's role in energy management and Vitamin D's effects on it
• Clinical trials: Vitamin D supplementation for athletes and older adults
• Importance of monitoring Vitamin D levels, especially in winter
• Target populations for Vitamin D benefits, including athletes and older adults

https://pubmed.ncbi.nlm.nih.gov/38766160/
https://link.springer.com/article/10.1007/s11033-022-07998-7
https://pmc.ncbi.nlm.nih.gov/articles/PMC6021354/

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In today’s episode of Daily Value, we explore the connection between B vitamins, and immune system, focusing on how dietary fiber fuels this relationship. While it’s well-known that fiber is essential for digestive health, new research (PMID: 39307855 - rodent data) demonstrates that it plays an even more complex role—boosting the available pool of B vitamins produced by gut bacteria, which in turn improved immune function. This episode will look at the interplay between gut bacteria, fiber, and the immune system, and how this trio could affect health outcomes.

Episode Talking Points:

*How dietary fiber influences the gut microbiota’s ability to produce B vitamins and increase the available pool of bacteria-produced B vitamins.

*The gut microbiome’s role in maintaining a healthy immune system through vitamin production, and how fiber deprivation can upset this balance.

*Research on fiber’s impact on gut health and immunity, revealing that fiber can promote anti-inflammatory immune cells and improve immune regulation.

These insights could redefine the way you think about fiber and nutrition.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01898-7

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In today’s episode of Daily Value, we continue our exploration of vitamins by diving into the concept of hypovitaminosis and the importance of adequate vitamin intake for overall health. The second half of the 20th century brought critical insights into how vitamin insufficiencies, or hypovitaminosis, can impact human health, even in populations where outright deficiencies are uncommon. We’ll explore the distinction between insufficiency and deficiency, how vitamin status is assessed, and the risks associated with marginal deficiencies that may affect up to 31% of the U.S. population.

Episode Talking Points:

*The difference between vitamin insufficiency, deficiency, and clinical manifestations.

*How socioeconomic factors and dietary choices can lead to hypovitaminosis, even in developed countries.

*The role of biomarkers in diagnosing vitamin deficiencies and the limitations of current testing methods.

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In today’s episode of Daily Value, we look at the protective effects of coffee, tea, and caffeine consumption on cardiometabolic health. A recent study published in the Journal of Clinical Endocrinology & Metabolism (doi:10.1210/clinem/dgae552) reveals how moderate caffeine intake—equivalent to a specific amount of caffeine—is related to the reduced risk of cardiometabolic multimorbidity, which includes coexistence of conditions like type 2 diabetes, coronary heart disease, and stroke.

Episode Talking Points:

• *The link between caffeine intake and reduced risk of developing cardiometabolic diseases.
• *Potential mechanisms of protection, including antioxidant and anti-inflammatory effects, improved lipid metabolism, and the role of specific compounds like chlorogenic acid and catechins.
• *Practical takeaways for incorporating moderate coffee or tea consumption into your daily routine for long-term heart health.

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae552/7754545?redirectedFrom=fulltext

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In today’s episode of Daily Value, we begin a special series called “The Vitamins,” where we’ll dive deep into the discovery, functions, and importance of vitamins in human health. This first episode lays the groundwork by exploring the history of vitamin discovery, from the 19th-century realization that certain diseases were tied to diet, to the revolutionary concept of vitamins and their role in preventing specific deficiency diseases. We’ll also cover key definitions, the defined physiological functions of vitamins, thereby allowing us to better understand how they impact our daily health.

Episode Talking Points:

• The historical context of vitamin discovery and how it changed the course of nutrition science.
• Defining vitamins: their essential role, how they differ from macronutrients, and the five-part definition of what makes a vitamin.
• The functions of vitamins in the body, from acting as coenzymes and antioxidants to influencing gene transcription.

Tune in to gain a deeper understanding of vitamins and their critical role in supporting overall health.

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In today’s episode of Daily Value, we take a closer look at a commonly overlooked but essential nutrient: vitamin B12. Known as cobalamin, vitamin B12 deficiency can lead to severe neurological, hematological, and cognitive issues if left unchecked. We’ll cover the causes behind this growing issue, from dietary intake to malabsorption.

Episode Talking Points:

• The role of B12 in nervous system function and red blood cell production.
• Causes of B12 deficiency, including dietary factors, autoimmune conditions, and genetic predispositions.
• Treatment approaches, including supplementation methods and the importance of early diagnosis.

https://pubmed.ncbi.nlm.nih.gov/38987879/

https://www.nature.com/articles/nrdp201740

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