Breaking Through
My Life in Science
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Narrated by:
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Eva Magyar
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By:
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Katalin Karikó
About this listen
A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines
“Katalin Karikó’s story is an inspiration.”—Bill Gates
“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry
A KIRKUS REVIEWS BEST BOOK OF THE YEAR
Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.
Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.
Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.
Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.
©2023 Katalin Karikó (P)2023 Random House AudioListeners also enjoyed...
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Critic reviews
“A riveting testament to resilience and the power of unwavering belief, Breaking Through charts an inspirational journey from growing up in postwar communist Hungary to transforming the world with mRNA.”—Jennifer Doudna, Nobel Prize laureate in chemistry and author of A Crack in Creation
“Katalin Karikó’s story is an inspiration. Anyone who has ever doubted that science, innovation, and persistence can change the world should read this book.”—Bill Gates, #1 New York Times bestselling author of How to Avoid a Climate Disaster
“Karikó’s proven recipe (from the creative Hungarian kitchen) for a breakthrough in science: Start with an insatiable curiosity in education and research. Then, for a few decades, look for gaps in knowledge; work hard for years to fill some of them; don’t give up because of difficulties or circumstances; and, finally, seize the opportunity to help solve one painful problem of humanity, thereby opening new horizons for the future of medicine. Bon appétit, enjoy your sweets!”—Ernő Rubik, inventor of the Rubik’s Cube and author of Cubed
“Katalin Karikó’s remarkable life story, which incidentally began not far from where I spent my childhood, inspires us not to be held back even in the face of severe difficulties. It encourages us to stay strong and follow through with important ideas that can change the world.”—Stefan Hell, Nobel Prize laureate in chemistry
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really expected more rigor from Michael Lewis
- By Wowhello on 10-04-23
By: Michael Lewis
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The Abyssinians
- By: Banna Desta
- Narrated by: Danielle Deadwyler, Phillip Brannon, André De Shields, and others
- Length: 1 hr and 43 mins
- Original Recording
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Royal intrigue takes center stage in The Abyssinians, a gripping new audio drama starring Danielle Deadwyler (Till, The Piano Lesson) delivering a masterful performance as a cunning queen navigating treacherous political waters and scheming sons. In the wake of King Ezana’s death, his brash widow Queen Yodit (Deadwyler) must decide which of her twin sons will ascend to the throne. Clashing beliefs about religion, duty, and the rights of a ruler collide in this unforgettable story about a royal house at a crossroads in history.
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Compelling Narration
- By Kitrail Hargrove on 12-07-24
By: Banna Desta
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The Madman's Hotel
- By: Niall Breslin
- Narrated by: Niall Breslin
- Length: 4 hrs and 4 mins
- Original Recording
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In the heart of the rolling green hills of Ireland a huge abandoned psychiatric asylum looms large and holds its secrets close, until one family fights to find the truth about their long lost great grandmother. Presented by Irish celebrity and mental health advocate Niall Breslin - this is the untold story of the quest to find patient Julia Leonard, alongside many others, who came to die in St Loman’s Hospital near Dublin. Why was Julia in St Loman’s? And what happened to her and other patients who found themselves within its walls?
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Heart felt Remembrance
- By RosaInGlousta on 11-05-24
By: Niall Breslin
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The Parole Room
- By: Ben Austen
- Narrated by: Ben Austen
- Length: 4 hrs and 25 mins
- Original Recording
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Will Johnnie Veal—convicted of the murder of two police officers in 1970—be granted parole after 50 years in prison? How can he convince the parole board he’s reformed when he insists he’s innocent? What is prison time even supposed to accomplish? These are the questions that propel The Parole Room forward as it builds toward Johnnie’s 20th parole hearing—after 19 rejections.
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Enlightening story & a must read
- By Patsy on 10-07-24
By: Ben Austen
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Maybe You Should Talk to Someone
- A Therapist, HER Therapist, and Our Lives Revealed
- By: Lori Gottlieb
- Narrated by: Brittany Pressley
- Length: 14 hrs and 21 mins
- Unabridged
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One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose office she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.
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It was like a hallmark movie being waterboarded into my ears for 15 hours
- By Amazon Customer on 10-01-19
By: Lori Gottlieb
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Genghis Khan and the Making of the Modern World
- By: Jack Weatherford
- Narrated by: Jonathan Davis, Jack Weatherford
- Length: 14 hrs and 20 mins
- Unabridged
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The Mongol army led by Genghis Khan subjugated more lands and people in 25 years than the Romans did in 400. In nearly every country the Mongols conquered, they brought an unprecedented rise in cultural communication, expanded trade, and a blossoming of civilization.
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Golden Horde/Platinum Listen
- By Cynthia on 12-11-13
By: Jack Weatherford
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Elvis and Me
- By: Priscilla Beaulieu Presley
- Narrated by: Priscilla Beaulieu Presley
- Length: 7 hrs and 30 mins
- Unabridged
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The inspiration for the major motion picture Priscilla directed by Sofia Coppola, this New York Times best seller reveals the intimate story of Elvis Presley and Priscilla Presley, told by the woman who lived it.
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What a story!
- By Pen Name on 08-28-22
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The Wonder of Stevie
- By: Wesley Morris
- Narrated by: Wesley Morris, Michelle Obama, Barack Obama, and others
- Length: 6 hrs and 10 mins
- Original Recording
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The year 1972 saw the beginning of a five-year span in which Stevie Wonder released five groundbreaking, critically acclaimed albums, garnering him more than half a dozen Grammys and more than 10 million albums sold, securing his place as one of the most important American musicians and songwriters in history. For the first time, uncover the untold story of an extraordinary artistic journey that shaped the greatest creative era in popular music history.
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Good but not great
- By Anonymous User on 09-14-24
By: Wesley Morris
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The Last Days of Cabrini-Green
- By: Ben Austen, Harrison David Rivers
- Narrated by: Ben Austen, Patina Miller, Harry Lennix, and others
- Length: 3 hrs and 32 mins
- Original Recording
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In 1992, the deadliest year in Chicago’s history, seven-year-old Dantrell Davis was shot and killed in front of his elementary school inside the public housing complex Cabrini-Green. What happened to Dantrell led to a truce among Chicago’s gangs, but it also ignited a national panic about poverty and violence in America’s cities. Dantrell’s name would soon be used to demolish all of Chicago’s high-rise public housing, displacing tens of thousands of low-income families.
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A Gripping and Necessary Work
- By booklover on 11-24-24
By: Ben Austen, and others
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San Miguel Kidnappings
- By: Erick Galindo, Roger Vela
- Narrated by: Karla Souza
- Length: 4 hrs and 50 mins
- Original Recording
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The close knit community in San Miguel de Allende Mexico was plagued by a string of sophisticated kidnappings for nearly a decade. When the police finally made an arrest the townspeople were shocked by who was accused of masterminding the criminal enterprise. It's everyone's favorite neighbor and a pillar of the community, Ramon Guerra. Except Ramon isn't who he says he is.
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Insightful
- By Tara on 12-11-24
By: Erick Galindo, and others
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The Book of Murder
- A Prosecutor's Journey Through Love and Death
- By: Matt Murphy
- Narrated by: Matt Murphy
- Length: 9 hrs and 59 mins
- Unabridged
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Examining murder from an insider’s perspective, Matt Murphy—a former senior deputy district attorney and current ABC News legal analyst—discusses cases from his career, how they strained his personal life, and how he found peace seeking justice for victims and their families. Part taxonomy of murder, part prosecutor’s handbook, and part personal memoir, The Book of Murder goes through a dozen cases and his recollections of his 26 years in the Orange County DA’s office (17 in the Homicide Unit).
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Fascinating true crime
- By RueRue on 12-19-24
By: Matt Murphy
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Problem Child
- By: Terrell Carter, Stacy Thunes
- Narrated by: Terrell Carter
- Length: 7 hrs and 34 mins
- Unabridged
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Problem Child is the unbelievably true story of Terrell Carter, an American musician and actor who grew up in Buffalo, New York, in a dysfunctional family, each member crazier than the next. And the Problem Child is the only one in the story who may, or may not, actually have a problem. An emotional journey of trials and revelations, with a huge secret at its core, this story may force you to laugh - just to keep from crying.
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Worth the wait . . .
- By JPALJ on 12-07-22
By: Terrell Carter, and others
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The Meaning of Mariah Carey
- By: Mariah Carey
- Narrated by: Mariah Carey
- Length: 11 hrs and 17 mins
- Unabridged
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It took me a lifetime to have the courage and the clarity to write my memoir. I want to tell the story of the moments - the ups and downs, the triumphs and traumas, the debacles and the dreams - that contributed to the person I am today. This book is composed of my memories, my mishaps, my struggles, my survival, and my songs. Unfiltered. I went deep into my childhood and gave the scared little girl inside of me a big voice. I let the abandoned and ambitious adolescent have her say, and the betrayed and triumphant woman I became tell her side.
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Entertaining glitz glam smoke and mirrors - not the whole story.
- By Anonymous User on 10-04-20
By: Mariah Carey
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The Autobiography of Malcolm X
- As Told to Alex Haley
- By: Malcolm X, Alex Haley
- Narrated by: Laurence Fishburne
- Length: 16 hrs and 52 mins
- Unabridged
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Experience a bold take on this classic autobiography as it’s performed by Oscar-nominated Laurence Fishburne. In this searing classic autobiography, originally published in 1965, Malcolm X, the Muslim leader, firebrand, and Black empowerment activist, tells the extraordinary story of his life and the growth of the Human Rights movement. His fascinating perspective on the lies and limitations of the American dream and the inherent racism in a society that denies its non-White citizens the opportunity to dream, gives extraordinary insight into the most urgent issues of our own time.
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it's Nearly perfect
- By Kerry on 09-16-20
By: Malcolm X, and others
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The Man Who Invented Christmas
- How Charles Dickens's A Christmas Carol Rescued His Career and Revived Our Holiday Spirits
- By: Les Standiford
- Narrated by: Jonathan Davis
- Length: 5 hrs and 50 mins
- Unabridged
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Just before Christmas in 1843, a debt-ridden and dispirited Charles Dickens wrote a small book he hoped would keep his creditors at bay. His publisher turned it down, so Dickens used what little money he had to put out A Christmas Carol himself. He worried it might be the end of his career as a novelist. The book immediately caused a sensation. And it breathed new life into a holiday that had fallen into disfavor, undermined by lingering Puritanism and the cold modernity of the Industrial Revolution.
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Beautifully Told!
- By JodyB on 12-01-17
By: Les Standiford
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In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth merchant, Antonie van Leeuwenhoek, look down their handmade microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences and altering both forever. It is the fact that complex living organisms are assemblages of tiny self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christens them 'cells'.
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The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
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Except for the author, this book is good!
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Must Read!
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The year was 1917. As a war raged across the world, young American women flocked to work, painting watches, clocks, and military dials with a special luminous substance made from radium. It was a fun job, lucrative and glamorous - the girls themselves shone brightly in the dark, covered head to toe in the dust from the paint. They were the radium girls. As the years passed, the women began to suffer from mysterious and crippling illnesses.
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Anthony Fauci is arguably the most famous–and most revered–doctor in the world today. His role guiding America sanely and calmly through Covid (and through the torrents of Trump) earned him the trust of millions during one of the most terrifying periods in modern American history, but this was only the most recent of the global epidemics in which Dr. Fauci played a major role. His crucial role in researching HIV and bringing AIDS into sympathetic public view and his leadership in navigating the Ebola, SARS, West Nile, and anthrax crises, make him truly an American hero.
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Must listen
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Acclaimed author Jonathan Rosen’s haunting investigation of the forces that led his closest childhood friend, Michael Laudor, from the heights of brilliant promise to the forensic psychiatric hospital where he has lived since killing the woman he loved. A story about friendship, love, and the price of self-delusion, The Best Minds explores the ways in which we understand—and fail to understand—mental illness.
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When we think of fungi, we likely think of mushrooms. But mushrooms are only fruiting bodies, analogous to apples on a tree. Most fungi live out of sight, yet make up a massively diverse kingdom of organisms that supports and sustains nearly all living systems. Fungi provide a key to understanding the planet on which we live, and the ways we think, feel, and behave.
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Mycology for Everyone
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A Fever in the Heartland
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The Roaring Twenties—the Jazz Age—has been characterized as a time of Gatsby frivolity. But it was also the height of the uniquely American hate group, the Ku Klux Klan. Their domain was not the old Confederacy, but the Heartland and the West. They hated Blacks, Jews, Catholics and immigrants in equal measure, and took radical steps to keep these people from the American promise. And the man who set in motion their takeover of great swaths of America was a charismatic charlatan named D.C. Stephenson.
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What listeners say about Breaking Through
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Jacob Rios
- 10-29-23
a must listen
this book is a must listen. it’s so inspirational and a lesson for how life should be lived.
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- José
- 01-10-24
Inspiring
Kaitlin's memoirs go beyond her major scientific advances to tell of her search for the unknown and her determination and resilience to find it, even without knowing that doing so would save millions of lives. One of the most inspiring stories I have read, but at the same time it reveals how there is a lot to do to support talent, especially women.
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- Linda Hart
- 11-21-23
Remarkable and inspiring story of grit and perseverance
Remarkable and inspiring story of grit and perseverance. Humanity should be forever grateful. Made me wonder how many researchers, particularly women, who quit before seeing the fruits of their labor because of poor leadership in their labs. The reader's accent created the belief that the book was delivered in the author's voice.
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- Michael Divricean
- 11-04-23
The most beautiful book
This is the best book I read in years!! Thank you Katalin Kariko for never giving up
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- Cathy
- 11-26-23
The power of curiosity, tenacity and integrity in Science.
Dr. Karikó’s description of her quest for knowledge is personal, candid and perspicacious. She is intensely driven by this quest and not the science gamesmanship which is so prevalent in academic institutions.
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- Amazon Kunde
- 04-22-24
Honest, encouraging and completely gripping
There is no way not to inspire by her. A story of determination and following what you believe in/experimenting, even though you’re not sure what it will bring you in the end. It is necessary for all to read, not just for woman in science.
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- Rahil Ghiasvand
- 03-24-24
Inspiring
As a newbie scientist and first Gen woman it was inspiring to hear her story.
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- Leo
- 09-20-24
Way better than W Isaacson’s book about J Doudna!!
Incredibly original, passionate story. It’s absolutely unbelievable that a Nobel prize winner with revolutionary research, published in 2006, would be squeezed out of her lab at the UPenn in 2013, would be told after 17 years of work there that she wasn’t a faculty material. That her breakthrough article would be outright rejected by Nature. Her patent for mRNA technology worth many billions would be sold for exclusive use for 300K by UPenn patent department etc. Unbelievable! With many billions spans on biology research, the system throws away 100 karat diamonds not once, but repeatedly!
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- Manfred Strutz
- 10-09-24
Excellent scientific information for a non scientific person!
I enjoyed both the description of the labs where she worked, the countries where she lived and the difficulties a person can encountered , specially being a woman !
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- Amazon Customer
- 11-08-23
Excellent book!
Excellent book! Read it. Wish everyone could read this book. It is a story of grit.
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