After 27 years of marriage and three children, Anna Oh - wife, mother, outsider artist - has fallen in love with Viveca, the wealthy Manhattan art dealer who orchestrated her success. They plan to wed in the Oh family’s hometown of Three Rivers in Connecticut. But the wedding provokes some very mixed reactions and opens a Pandora’s Box of toxic secrets - dark and painful truths that have festered below the surface of the Ohs' lives.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

Forrmer academic Arthur Opp weighs 550 pounds and hasn’t left his rambling Brooklyn home in a decade. Twenty miles away in Yonkers, seventeen-year-old Kel Keller navigates life as the poor kid in a rich school and pins his hopes on what seems like a promising baseball career - if he can untangle himself from his family drama.

Rachel Blum and Andy Landis are eight years old when they meet late one night in an ER waiting room. Born with a congenital heart defect, Rachel is a veteran of hospitals, and she's intrigued by the boy who shows up all alone with a broken arm. He tells her his name. She tells him a story. After Andy's taken back to the emergency room and Rachel's sent back to her bed, they think they'll never see each other again.

From marriage, infidelity, and the mayhem of motherhood to scandal, tragedy, and illness - three women seek peace and comfort in Nantucket as they cope with life's challenges. Three women - burdened with small children, unwieldy straw hats, and some obvious emotional issues - tumble onto the Nantucket airport tarmac one hot June day. Vicki is trying to sort through the news that she has a serious illness. Her sister, Brenda, has just left her job after being caught in an affair with a student. And their friend Melanie, after seven failed in vitro attempts, is pregnant at last.

A warm June evening, a local tradition: The students of Nantucket High have gathered for a bonfire on the beach. But what begins as a graduation night celebration ends in tragedy after a horrible car crash leaves the driver of the car, Penny Alistair, dead and her twin brother in a coma. The other passengers - Penny's boyfriend Jake and her friend Demeter - are physically unhurt, but the emotional damage is overwhelming, and questions linger about what happened before Penny took the wheel.

In the spring of 1981, the young Skinner siblings - fierce Renee, dreamy Caroline, golden boy Joe, and watchful Fiona - lose their father to a heart attack and their mother to a paralyzing depression, events that thrust them into a period they will later call “the Pause”. Caught between the predictable life they once led and an uncertain future that stretches before them, the siblings navigate the dangers and resentments of the Pause to emerge fiercely loyal and deeply connected. Two decades later, the Skinners find themselves again confronted with a family crisis....

Fifteen years ago, Vida Avery arrived alone and pregnant at elite Fayer Academy. By living on campus, on an island off the New England coast, Vida has cocooned herself and her son, Peter, from the outside world and from an inside secret. For years, she has lived largely through the books she teaches, but when she accepts the impulsive marriage proposal of ardent widower Tom Belou, the prescribed life Vida has constructed is swiftly dismantled.

Every summer the Newton family retreats to their beloved home on Nantucket for three months of sunshine, cookouts, and bonfires on the beach. But this summer will not be like any other. When Arch Newton, a prominent New York attorney, dies in a plane crash on his way home from a business trip, his beautiful widow, Beth, can barely keep things together. Above all, though, she decides that she must continue the family tradition of going to Nantucket, and at the same time fulfill a promise that Arch made before he died.

In April 2002, Janine Latus' youngest sister, Amy, wrote a note and taped it to the inside of her desk drawer. "Today Ron Ball and I are romantically involved", it read, "but I fear I have placed myself at risk in a variety of ways. Based on his criminal past, writing this out just seems like the smart thing to do. If I am missing or dead this obviously has not protected me...."

Henry Page has never been in love. He fancies himself a hopeless romantic, but the slo-mo, heart palpitating, can't-eat-can't-sleep kind of love that he's been hoping for just hasn't been in the cards for him - at least not yet. Instead he's been happy to focus on his grades, on getting into a semi-decent college, and finally becoming editor of his school newspaper. Then Grace Town walks into his first period class on the third Tuesday of senior year, and he knows everything's about to change.

Dr. Julie Walker wakes on a summer morning in San Francisco to find a city in chaos. Today Californians are voting on a controversial ballot initiative that will change history. With the future of the state and the nation uncertain, the streets have erupted into violence. Injured, Julie must make her way across the city by foot to the Veterans Administration Hospital, where her sister, recently returned from Afghanistan, is in labor. At the hospital a brutal scene is unfolding as a man who shares an intimate past with Julie begins to take his revenge.

In 1962 a pregnant girl staggers into a health clinic, gives birth, and flees. A foster family takes the baby in, and an unlikely couple, their lives unspooling from the recent death of their infant, adopts her. Forty years and many secrets and lies later, Cheri Matzner is all grown up and falling apart. Ironic and fierce, she's a former cop turned disgruntled academic, a frustrated wife trying to get pregnant, an iconoclastic daughter bearing war wounds from her dysfunctional family.