A bold and all-embracing exploration of the nature and progress of knowledge from one of today's great thinkers. Throughout history, mankind has struggled to understand life's mysteries, from the mundane to the seemingly miraculous. In this important new book, David Deutsch, an award-winning pioneer in the field of quantum computation, argues that explanations have a fundamental place in the universe.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

Bacteria form a fundamental branch of life. They are the oldest forms of life and the most prolific of all living organisms, inhabiting every part of the Earth's surface, its ocean depths, and even such inhospitable places as boiling hot springs. In this Very Short Introduction, bacteriologist Sebastian Amyes explores the nature of bacteria, their origin and evolution, bacteria in the environment, and bacteria and disease.

Written by experts and authorities in the field and professionally narrated for easy listening, this crash course is a valuable tool both during school and when preparing for the USMLE, or if you're simply interested in the subject.

The audio is focused and high-yield, covering the most important topics you might expect to learn in a typical Medical school Pathology course. Included are both capsule and detailed explanations of critical issues and topics you must know to master the course.

Challenging leading scientific theories that claim that our senses report back objective reality, cognitive scientist Donald Hoffman argues that while we should take our perceptions seriously, we should not take them literally. How can it be possible that the world we see is not objective reality? And how can our senses be useful if they are not communicating the truth? Hoffman grapples with these questions and more over the course of this eye-opening work.

Just over 125,000 years ago, humanity was going extinct until a dramatic shift occurred—Homo sapiens started tracking the tides in order to eat the nearby oysters. Before long, they’d pulled themselves back from the brink of extinction. The human brain, and its evolutionary journey, is unlike anything else in history. In A History of the Human Brain, Bret Stetka takes listeners through that far-reaching journey. He also tackles the question of where the brain will take us next, exploring the burgeoning con­cepts of epigenetics and new technologies like CRISPR.

The beauty of fractal patterns and their relation to chaos, as well as the history of chaos, and its uses in the real world and implications for the philosophy of science are all discussed in this Very Short Introduction audiobook.

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were - and still are. The Structure of Scientific Revolutions is that kind of book.

The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".

Many people take math in high school and promptly forget much of it. But math plays a part in all of our lives all of the time, whether we know it or not. In The Joy of x, Steven Strogatz expands on his hit New York Times series to explain the big ideas of math gently and clearly, with wit, and insight.

In the years following her role as the lead author of the international best seller, Limits to Growth - the first book to show the consequences of unchecked growth on a finite planet - Donella Meadows remained a pioneer of environmental and social analysis until her untimely death in 2001. Thinking in Systems is a concise and crucial book offering insight for problem-solving on scales ranging from the personal to the global. Edited by the Sustainability Institute's Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world....

Enzymes are the astonishing tiny molecular machines that make life possible. Each one of these small proteins speeds up a single chemical reaction inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that collectively we recognize as life, from making DNA to digesting food. This Very Short Introduction explains the why and the how of speeding up these reactions - catalysis - before going on to reveal how we have evolved these catalysts of such extraordinary power and exquisite selectivity.

The cells in our bodies consist of molecules, made up of the same carbon, oxygen, and hydrogen atoms found in air and rocks. But molecules, such as water and sugar, are not alive. So how do our cells - assemblies of otherwise "dead" molecules - come to life, and together constitute a living being? In Life’s Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale.

In this fascinating and thought-provoking book, author Nick Lane brings together the latest research findings in the exciting field of mitochondria research to reveal how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death.

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.

What is life? Humans have been asking this question for thousands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells, and whole organisms to create new ones that could never have previously existed on their own.

Seventy years ago, Erwin Schrdinger posed a simple, yet profound, question: What is life?. How could the very existence of such extraordinary chemical systems be understood? This problem has puzzled biologists and physical scientists both before, and ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology?

The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.

The cells in our bodies consist of molecules, made up of the same carbon, oxygen, and hydrogen atoms found in air and rocks. But molecules, such as water and sugar, are not alive. So how do our cells - assemblies of otherwise "dead" molecules - come to life, and together constitute a living being? In Life’s Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale.

Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.

K. Eric Drexler is the founding father of nanotechnology - the science of engineering on a molecular level. In Radical Abundance, he shows how rapid scientific progress is about to change our world. Thanks to atomically precise manufacturing, we will soon have the power to produce radically more of what people want, and at a lower cost. The result will shake the very foundations of our economy and environment.

Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?

In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over 15 years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.

In The Equations of Life, biologist Charles S. Cockell makes the forceful argument that the laws of physics narrowly constrain how life can evolve, making evolution's outcomes predictable. If we were to find something very much like a lady bug eating something very much like an aphid on a distant planet, we shouldn't be surprised. The forms of life are guided by a limited set of rules, and, as a result, there is a narrow set of solutions to the challenges of existence.

What is economic growth? And why, historically, has it occurred in only a few places? Previous efforts to answer these questions have focused on institutions, geography, finances, and psychology. But according to MIT's anti-disciplinarian César Hidalgo, understanding the nature of economic growth demands transcending the social sciences and including the natural sciences of information, networks, and complexity. To understand the growth of economies, Hidalgo argues, we first need to understand the growth of order.

Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25 percent of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals but not because we are evolutionary outliers.

This new book by Spencer Wells, the internationally known geneticist, anthropologist, author, and director of the Genographic Project, focuses on the seminal event in human history: mankind's decision to become farmers rather than hunter-gatherers.

Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: Nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?

What is time? What does it mean for time to pass? Is it possible to travel in time? What is the difference between the past and future? Until the work of Newton, these questions were purely topics of philosophical speculation. Since then we've learned a great deal about time, and its study has moved from a subject of philosophical reflection to instead became part of the subject matter of physics.

Leofranc Holford-Strevens brings us this fascinating study of time using a range of examples from ancient Rome and Julius Caesar's imposition of the leap year to the 1920s project for a fixed Easter. Those interested in time, history, and the development of the calendar will enjoy this absorbing exploration of an aspect of our lives that we all take for granted.

The laws of thermodynamics drive everything that happens in the universe. From the sudden expansion of a cloud of gas to the cooling of hot metal - everything is moved or restrained by four simple laws. This powerful and compact introduction explains what these four laws are and how they work, using accessible language and virtually no mathematics.

In this new edition, Steve Bruce discusses the continuing arguments for social egalitarianism, considering issues such as gay marriage, women in combat roles, and the 2010 Equality Act to debunk contemporary arguments against parity. As gender divisions are increasingly questioned, he looks ahead to the likely consequences of this for society.

In this Very Short Introduction audiobook, Christopher Taylor explores the life of Socrates and his philosophical activity, before looking to the responses his philosophical doctrines have evoked in the centuries since his betrayal and execution at fellow Athenian hands.

In this Very Short Introduction, Gerhard L. Weinberg provides an introduction to the origins, course, and impact of the war on those who fought and the ordinary citizens who lived through it. Starting by looking at the inter-war years and the German invasion of Poland in September 1939, he examines how the war progressed by examining a number of key events, including the war in the West in 1940, Barbarossa, the German Invasion of the Soviet Union, the expansion of Japan's war with China, developments on the home front, and the Allied victory from 1944-45.

This Very Short Introduction introduces listeners to the key concepts of political philosophy: authority, democracy, freedom and its limits, justice, feminism, multiculturalism, and nationality. Accessible and assuming no previous knowledge of the subject, it encourages the listener to think clearly and critically about the leading political questions of our time. Miller first investigates how political philosophy tackles basic ethical questions such as "how should we live together in society?"

Number theory is the branch of mathematics that is primarily concerned with the counting numbers. Of particular importance are the prime numbers, the "building blocks" of our number system. The subject is an old one, dating back over two millennia to the ancient Greeks, and for many years has been studied for its intrinsic beauty and elegance, not least because several of its challenges are so easy to state that everyone can understand them, and yet no one has ever been able to resolve them. But number theory has also recently become of great practical importance.

Timothy Williamson tackles some of the key questions surrounding philosophy in new and provocative ways, showing how philosophy begins in common sense curiosity, and develops through our capacity to dispute rationally with each other. Discussing philosophy's ability to clarify our thoughts, he explains why such clarification depends on the development of philosophical theories, and how those theories can be tested by imaginative thought experiments, and compared against each other by standards similar to those used in the natural and social sciences.

In this Very Short Introduction audiobook, Richard Earl gives a sense of the more visual elements of topology (looking at surfaces) as well as covering the formal definition of continuity. Considering some of the eye-opening examples that led mathematicians to recognize a need for studying topology, he pays homage to the historical people, problems, and surprises that have propelled the growth of this field.

How does the brain work? How different is a human brain from other creatures' brains? Is the human brain still evolving? In this fascinating book, Michael O'Shea provides a non-technical introduction to the main issues and findings in current brain research, and gives a sense of how neuroscience addresses questions about the relationship between the brain and the mind.